Neuroendocrinology of Social Behavior
Neuroendocrinology of Social Behavior
复制标题
DOI：
10.1093/ilar.50.1.5
复制
发表时间：
2009-01-01
期刊：
影响因子：
2.5
通讯作者：
Adkins-Regan, Elizabeth
中科院分区：
文献类型：
--
作者：
Adkins-Regan, Elizabeth
发现促进亲和性社会行为的激素和神经机制是行为神经科学的当务之急。虽然对标准实验室啮齿类动物的研究提供了许多重要的见解，但通过对社会性不同或形成社会一夫一妻制的非标准物种的比较研究，也出现了令人兴奋的进展，这些工作通常由明确的进化观点提供信息。对草原田鼠的研究考察了性类固醇激素、肾上腺糖皮质激素、催产素家族肽和多巴胺在一夫一妻制伴侣形成中的作用。皮质酮促进雄性配对，但抑制雌性配对，抗利尿激素（通过V1a受体起作用）和催产素促进配对，伏隔核中的多巴胺也促进配对。对斑胸草雀的研究正在测试这些机制的普遍性的极限，并显示了性类固醇在生命早期的作用以及社会经验如何导致成年后对伴侣的性偏好。在胚胎期或雏鸟时期雌激素的操纵导致雌性更喜欢与其他雌性交配。一个全是女性的社会环境可以强化这种效应，也可以产生雄性和雌性的配偶。对多物种的研究揭示了多肽能和多巴胺能机制对物种差异进化的贡献，即动物是群居还是领土。这类鸟类的社会性预测了脑间隔区血管催产素（鸟类抗利尿激素）的机制和反应。
Discovering the hormonal and neural mechanisms that promote affiliative social behavior is a high priority in behavioral neuroscience. Although studies with standard laboratory rodents have afforded many important insights, exciting advances are also occurring through comparative research with nonstandard species that vary in sociality or form socially monogamous pair bonds, work that is often informed by an explicitly evolutionary perspective. Research with prairie voles has examined the roles of sex steroid hormones, adrenal glucocorticoids, oxytocin family peptides, and dopamine in the formation of monogamous pairs. Corticosterone facilitates pairing by males but inhibits it in females, vasopressin (acting via the V1a receptor) and oxytocin facilitate pairing, and dopamine in the nucleus accumbens also facilitates pairing. Research with zebra finches is testing the limits of generality of these mechanisms, and has shown how sex steroid effects early in life along with social experience lead to an adult's sex preference in a pairing partner. Estrogen manipulations during the embryonic or nestling periods result in females that prefer to pair with other females. An all-female social environment can reinforce such effects, and can also produce males and females that will pair with either sex. Research with multiple species of estrildid finches is revealing the contributions of peptidergic and dopaminergic mechanisms to the evolution of species differences in whether animals are gregarious or territorial. Mechanisms for and responses to vasotocin (avian vasopressin) in the septal region of the brain are predicted by sociality in this group of birds.