Telomere length variation: A potential new telomere biomarker for lung cancer risk.
Telomere length variation: A potential new telomere biomarker for lung cancer risk.
复制标题
端粒长度变化：一种潜在的新型端粒生物标志物，用于肺癌风险。
DOI：
10.1016/j.lungcan.2015.03.011
复制
发表时间：
2015-06
期刊：
影响因子：
--
通讯作者：
Zheng YL
中科院分区：
文献类型：
--
作者：
Sun B;Wang Y;Kota K;Shi Y;Motlak S;Makambi K;Loffredo CA;Shields PG;Yang Q;Harris CC;Zheng YL
在这份报告中，端粒长度变异（TLV），平均端粒长度在血液淋巴细胞和肺癌风险之间的关系进行了检查。研究设计为病例对照。病例（N = 191）为新诊断的经组织学证实的非小细胞肺癌患者。对照组（N = 207）为来自病例所在县的健康人，年龄和性别与病例匹配。端粒荧光原位杂交技术用于测量端粒的功能，使用短期培养的血淋巴细胞。Logistic回归用于估计端粒特征与肺癌风险之间的关联强度。所有染色体末端的端粒长度变异与肺癌风险显著相关;年轻（年龄≤ 60岁）和老年（年龄> 60岁）个体的校正比值比分别为4.67 [95%置信区间（CI）：1.46 - 14.9]和0.46（95% CI：0.25 - 0.84）。TLV和平均端粒长度共同影响肺癌风险：当比较端粒长度短、TLV高的个体与端粒长度长、TLV低的个体时，年轻和老年个体的校正比值比分别为8.21（95%CI：1.71 - 39.5）和0.33（95%CI：0.15 - 0.72）。血液淋巴细胞中的TLV与肺癌风险显著相关，并且这种相关性受年龄的影响。TLV联合端粒长度可作为肺癌CT筛查的高危人群。
In this report the associations between telomere length variation (TLV), mean telomere length in blood lymphocytes and lung cancer risk were examined. The study design is case-control. Cases (N = 191) were patients newly diagnosed with histologically confirmed non-small cell lung cancer. Controls (N = 207) were healthy individuals recruited from the same counties as cases and matched to cases on age and gender. Telomere fluorescent in situ hybridization was used to measure telomere features using short-term cultured blood lymphocytes. Logistic regression was used to estimate the strength of association between telomere features and lung cancer risk. Telomere length variation across all chromosomal ends was significantly associated with lung cancer risk; adjusted odds ratios 4.67 [95% confidence interval (CI): 1.46 – 14.9] and 0.46 (95% CI: 0.25 – 0.84) for younger (age ≤ 60) and older (age > 60) individuals, respectively. TLV and mean telomere length jointly affected lung cancer risk: when comparing individuals with short telomere length and high TLV to those with long telomere length and low TLV, adjusted odd ratios were 8.21 (95% CI: 1.71 – 39.5) and 0.33 (95% CI: 0.15 – 0.72) for younger and older individuals, respectively. TLV in blood lymphocytes is significantly associated with lung cancer risk and the associations were modulated by age. TLV in combination with mean telomere length might be useful in identifying high risk population for lung cancer computerized tomography screening.