Steroids, carbogen or placebo for sudden hearing loss: a prospective double-blind study
Steroids, carbogen or placebo for sudden hearing loss: a prospective double-blind study
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DOI：
10.1007/s004050100366
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发表时间：
2001-11-01
影响因子：
2.6
通讯作者：
Kronenberg, J
中科院分区：
文献类型：
--
作者：
Cinamon, U;Bendet, E;Kronenberg, J
对于特发性突发性感音神经性听力损失（SNHL）的治疗方式尚无共识。为了评估类固醇或碳吸入治疗的有效性，设计了一项前瞻性双盲安慰剂对照研究。所有41例纳入研究的患者均为单侧SNHL，既往无SNHL病史、耳科病理史或耳镜检查结果。患者被分为四个治疗组：强的松片、安慰剂片、碳吸入或室内空气吸入。所有患者均治疗5 d。将入院时的听力数据与第6天的听力数据和随访时（平均33天）的听力数据进行比较。结果显示各组间早期或晚期听力学结果无显著差异。年龄、从症状出现到开始治疗的时间、耳鸣、听音图配置和发病时是否存在眩晕对结果没有显著影响。入院时所有患者组中较差的歧视评分在几天内都有所改善。这些发现表明类固醇或吸入碳没有安慰剂的治疗优势。此外，无论治疗方式如何，听力在停止治疗后至少持续改善一个月。
There is no consensus regarding treatment modalities for idiopathic sudden sensorineural hearing loss (SNHL). In order to evaluate the effectiveness of steroid or carbogen inhalation therapies, a prospective double-blind placebo controlled study was designed. All 41 patients enrolled in the study had unilateral SNHL with no prior history of SNHL, otological pathological history or otoscopic findings. Patients were assigned to four treatment groups: prednisone tablets, placebo tablets, carbogen inhalation or room air inhalation. All were treated for 5 days. The audiometric data at admission was compared to that at day 6 and to data collected at follow-up (average 33 days). Results revealed no significant difference between the groups for early or late audiometric outcome. Age, time from onset of symptoms to initiation of treatment, tinnitus, audiogram configuration, and the presence of vertigo at onset did not significantly affect the outcome. The discrimination scores that were poor in all patient groups on admission improved within days in all groups. These findings suggest that steroids or carbogen inhalation have no therapeutic advantage over placebo. Also, regardless of treatment modality, hearing continued to improve for at least a month after treatment was stopped.