Neutrophil-lymphocyte ratio predicts response to chemotherapy in triple-negative breast cancer
Neutrophil-lymphocyte ratio predicts response to chemotherapy in triple-negative breast cancer
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DOI：
10.3747/co.25.3888
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发表时间：
2018-04-01
期刊：
影响因子：
2.6
通讯作者：
Kim, E. K.
中科院分区：
文献类型：
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作者：
Chae, S.;Kang, K. M.;Kim, E. K.
背景：嗜中性粒细胞-淋巴细胞比率（NLR）已被报道与包括乳腺癌在内的几种癌症患者的预后相关。我们评估了NLR是否可以作为三阴性乳腺癌（TNBC）患者新辅助化疗（NAC）后病理完全缓解（PCR）的预测因素。方法我们分析了87例接受NAC的TNBC患者对NAC的反应与各种因素之间的相关性，包括NLR。此外，我们分析了NLR与TNBC患者无复发生存期（RFS）之间的关系。结果87例患者中，25例（28.7%）达到PCR。高Ki-67指数和低NLR与PCR显著相关。Ki-67指数高的患者（>= 15%）的PCR率高于Ki-67指数低的患者（35.7%对0%，p = 0.002），NLR低的患者（
Background The neutrophil-lymphocyte ratio (NLR) has been reported to correlate with patient outcome in several cancers, including breast cancer. We evaluated whether the NLR can be a predictive factor for pathologic complete response (PCR) after neoadjuvant chemotherapy (NAC) in patients with triple-negative breast cancer (TNBC).Methods We analyzed the correlation between response to NAC and various factors, including the NLR, in 87 patients with TNBC who underwent NAC. In addition, we analyzed the association between the NLR and recurrence-free survival (RFS) in patients with TNBC.Results Of the 87 patients, 25 (28.7%) achieved a PCR. A high Ki-67 index and a low NLR were significantly associated with PCR. The PCR rate was higher in patients having a high Ki-67 index (>= 15%) than in those having a low Ki-67 index (35.7% vs. 0%, p = 0.002) and higher in patients having a low NLR (