Is EBV persistence in vivo a model for B cell homeostasis?
Is EBV persistence in vivo a model for B cell homeostasis?
复制标题
DOI：
10.1016/s1074-7613(00)80493-8
复制
发表时间：
1996-08-01
期刊：
影响因子：
32.4
通讯作者：
ThorleyLawson, DA
中科院分区：
文献类型：
--
作者：
Khan, G;Miyashita, EM;ThorleyLawson, DA
我们测量了健康持续感染个体外周血中ebv感染B细胞的绝对数量。对15个健康个体的单次测量表明，频率在每10(6)个B细胞1-50之间变化很大。在1-3.5年的时间里，对几个频率变化超过10倍的个体进行重复测量，结果表明，这种变化并不代表个体内部可能发生的频率波动；相反，频率是特定于个人的。随着时间的推移，个体内的频率测量是稳定的，对整个人群中所见方差的贡献小于10%。这些测量结果表明，eb病毒感染的B细胞水平受到严格调节，我们提出调节正常B细胞水平的相同稳态机制也调节潜伏感染eb病毒的B细胞。
We have measured the absolute numbers of EBV-infected B cells in the peripheral blood of healthy persistently infected individuals. Single measurements on a panel of 15 healthy individuals demonstrate that the frequency varies over a wide range from 1-50 per 10(6) B cells. Repeat measurements over 1-3.5 years on several individuals whose frequencies varied over a 10-fold range showed that the variation does not represent the fluctuation in the frequency that can occur within an individual; rather, the frequencies are specific to the individual. The frequency within an individual measured over time is stable and contributes less than 10% to the variance seen in the whole population. These measurements suggest that the level of EBV-infected B cells is tightly regulated and we propose that the same homeostatic mechanisms that regulate the levels of normal B cells also regulate B cells latently infected with EBV.