Cell wall active antifungal compounds produced by the marine fungus Hypoxylon oceanicum LL-15G256
Cell wall active antifungal compounds produced by the marine fungus Hypoxylon oceanicum LL-15G256
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DOI：
10.7164/antibiotics.51.296
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发表时间：
1998-03-01
影响因子：
3.3
通讯作者：
Greestein, M
中科院分区：
文献类型：
--
作者：
Abbanat, D;Leighton, M;Greestein, M
海洋炭团菌LL-15 G256提取物的细胞壁靶向抗真菌活性来自于新型脂缩肽和先前报道的大环聚内酯的产生。在优化的培养基中，脂缩肽和聚内酯的滴度分别达到约200（相当于400毫克/升）和25（相当于50毫克/升）。15 G256 γ的最适发酵温度为28 ℃。在较低的发酵温度下，海水似乎对代谢产物积累有抑制作用。
The cell wall targeted antifungal activity of Hypoxylon oceanicum LL-15G256 extracts resulted from the production of novel lipodepsipeptides and previously reported macrocyclic polylactones. In an optimized medium, titers of the lipodepsipeptide and the polylactones reached approximately 200 similar to 400 mg/liter and 25 similar to 50 mg/liter, respectively. The optimum fermentation temperature for production of 15G256 gamma was 28 degrees C. Seawater appeared to have an inhibitory effect on metabolite accumulation at lower fermentation temperatures.