Atorvastatin suppresses glioma invasion and migration by reducing microglial MT1-MMP expression
Atorvastatin suppresses glioma invasion and migration by reducing microglial MT1-MMP expression
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阿托伐他汀通过减少小胶质细胞 MT1-MMP 表达抑制胶质瘤侵袭和迁移
DOI：
10.1016/j.jneuroim.2013.04.020
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发表时间：
2013-07-15
影响因子：
3.3
通讯作者：
Ke Yiquan
中科院分区：
文献类型：
--
作者：
Yi Yongjun;Huang Shuyun;Ke Yiquan
小胶质细胞是大脑的免疫细胞，通常大量存在于胶质瘤中，促进肿瘤生长和侵袭。本研究发现，阿托伐他汀通过降低膜1型金属蛋白酶（MT1-MMP）的小胶质细胞表达，降低了小胶质细胞对胶质瘤迁移和侵袭的致瘤作用。结果表明，小胶质细胞中MT1-MMP的下调受p38 MAPK通路的控制。综上所述，结果支持进一步研究阿托伐他汀作为靶向小胶质细胞治疗胶质瘤的候选药物。(C) 2013 Elsevier B.V.版权所有
Microglia, the immune cells of the brain, often present in large numbers in gliomas, where they promote tumor growth and invasiveness. This study found that atorvastatin reduced the pro-tumorigenic effects of microglia on glioma migration and invasion by reducing the microglial expression of membrane type 1 metalloproteinase (MT1-MMP). The results suggest that down-regulation of MT1-MMP is controlled by a p38 MAPK pathway in microglia. Taken together, the results support further research on atorvastatin as a candidate for glioma therapy by targeting microglia. (C) 2013 Elsevier B.V. All rights reserved.