CD16+ monocytes exposed to HIV promote highly efficient viral replication upon differentiation into macrophages and interaction with T cells
CD16+ monocytes exposed to HIV promote highly efficient viral replication upon differentiation into macrophages and interaction with T cells
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DOI：
10.1016/j.virol.2005.10.027
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发表时间：
2006-01-20
期刊：
影响因子：
3.7
通讯作者：
Gabuzda, D
中科院分区：
文献类型：
--
作者：
Ancuta, P;Kuntsman, KJ;Gabuzda, D
在艾滋病的发展过程中，外周血中单核细胞的CD 16（+）亚群急剧扩增，但其对HIV发病机制的作用尚不清楚。在这里，我们证明了CD 16（+）而不是CD 16（-）单核细胞促进高水平的HIV复制分化成巨噬细胞和与T细胞的相互作用。CD 16（+）单核细胞衍生的巨噬细胞和T细胞之间形成的结合物是病毒复制的主要位点。此外，在HIV感染患者的外周血中检测到类似的单核细胞-T细胞缀合物含有HIV DNA。因此，在HIV感染过程中，CD 16（+）单核细胞的扩增及其随后募集到淋巴结、脑和肠等组织中可能有助于HIV传播和在T细胞中建立生产性感染。(C)2005年爱思唯尔公司All rights reserved.
The CD16(+) subset of monocytes is dramatically expanded in peripheral blood during progression to AIDS, but its contribution to HIV pathogenesis is unknown. Here, we demonstrate that CD16(+) but not CD16(-) monocytes promote high levels of HIV replication upon differentiation into macrophages and interaction with T cells. Conjugates formed between CD16(+) monocyte-derived macrophages and T cells are major sites of viral replication. Furthermore, similar monocyte-T cell conjugates detected in peripheral blood of HIV-infected patients harbor HIV DNA. Thus, expansion of CD16(+) monocytes during HIV infection and their subsequent recruitment into tissues such as lymph nodes, brain, and intestine may contribute to HIV dissemination and establishment of productive infection in T cells. (C) 2005 Elsevier Inc. All rights reserved.