Hippocampus and entorhinal cortex in mild cognitive impairment and early AD
Hippocampus and entorhinal cortex in mild cognitive impairment and early AD
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DOI：
10.1016/s0197-4580(03)00084-8
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发表时间：
2004-03-01
影响因子：
4.2
通讯作者：
Soininen, H
中科院分区：
文献类型：
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作者：
Pennanen, C;Kivipelto, M;Soininen, H
磁共振成像(MRI)已被认为是阿尔茨海默病(AD)早期诊断的有用工具。基于磁共振成像的体积，我们研究了59名对照组、65名轻度认知障碍(MCI)患者和48名AD患者的海马区和内嗅区皮质(ERC)。对照组和患有MCI的个体来自基于人群的队列。海马区和ERC的体积按以下顺序显著减小：对照组>；MCI>；AD。逐步判别函数分析显示，在对照组和MCI受试者之间，ERC测量获得了最有效的总体分类(65.9%)。然而，在对照组和AD患者之间(90.7%)，以及在MCI患者和AD患者之间(82.3%)，最好的总体分类是以海马体体积为指标。我们的结果表明，在AD中，ERC萎缩先于海马区萎缩。MCI组以ERC体积丢失为主，而轻度AD组以ERC体积丢失为主。(C)2003 Elsevier Science Inc.保留所有权利。
Magnetic resonance imaging (MRI) has been suggested as a useful tool in early diagnosis of Alzheimer's disease (AD). Based on MRI-derived volumes, we studied the hippocampus and entorhinal cortex (ERC) in 59 controls, 65 individuals with mild cognitive impairment (MCI) and 48 patients with AD. The controls and individuals with MCI were derived from population-based cohorts. Volumes of the hippocampus and ERC were significantly reduced in the following order: control > MCI > AD. Stepwise discriminant function analysis showed that the most efficient overall classification between controls and individuals with MCI subjects was achieved with ERC measurements (65.9%). However, the best overall classification between controls and AD patients (90.7%), and between individuals with MCI and AD patients (82.3%) was achieved with hippocampal volumes. Our results suggest that the ERC atrophy precedes hippocampal atrophy in AD. The ERC volume loss is dominant over the hippocampal volume loss in MCI, whereas more pronounced hippocampal volume loss appears in mild AD. (C) 2003 Elsevier Science Inc. All rights reserved.