Magnetic resonance labeling of stem cells: is positive tracking a plus or a minus?
Magnetic resonance labeling of stem cells: is positive tracking a plus or a minus?
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干细胞的磁共振标记：阳性追踪是加号还是减号？
DOI：
10.1016/j.jcmg.2009.05.010
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Caravan,Peter
中科院分区：
文献类型：
--
作者：
Kraitchman,DaraL;Caravan,Peter
最近对心血管疾病临床细胞疗法试验的荟萃分析表明，这些疗法是安全的，可能会产生积极的治疗益处（1-5）。然而，困扰这些临床研究的一个问题是无法确定外源性施用的干细胞的植入百分比和干细胞命运。在本期iJACC中，Adler et al. (6)提出了一种基于顺磁剂钆的心脏磁共振（CMR）造影剂，以跟踪胚胎干细胞衍生的心血管祖细胞的植入。
Recent meta-analyses of clinical cellular therapy trials in cardiovascular disease have shown that these therapies are safe and perhaps yield a positive therapeutic benefit (1–5). However, 1 issue that has plagued these clinical studies is the inability to determine the percentage engraftment of exogenously administered stem cells and the stem cell fate. In this issue of iJACC, Adler et al.(6) propose a cardiac magnetic resonance (CMR) contrast based on a paramagnetic agent, gadolinium, to track the engraftment of embryonic stem cell-derived cardiovascular progenitor cells.