Dedifferentiated Chromophobe Renal Cell Carcinoma With Massive Osteosarcoma-Like Divergent Differentiation: A Singular Entity in the Spectrum of Retroperitoneal Calcifying Tumors
Dedifferentiated Chromophobe Renal Cell Carcinoma With Massive Osteosarcoma-Like Divergent Differentiation: A Singular Entity in the Spectrum of Retroperitoneal Calcifying Tumors
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DOI：
10.1177/1066896908329414
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发表时间：
2010-10-01
影响因子：
1.2
通讯作者：
Corradi, Domenico
中科院分区：
文献类型：
--
作者：
Gira, Federica A.;Barbieri, Antonio;Corradi, Domenico
肾细胞癌的肉瘤样改变是“母体”肿瘤向高级别恶性肿瘤去分化的结果，其特征为肉瘤样特征，并与临床病程加快和预后较差有关。任何肾细胞癌亚型都可以经历肉瘤样去分化，其中恐色变异体是最容易发生的。本报告描述了一例典型的憎色性肾细胞癌患者，其发展为去分化并伴有非常罕见的骨肉瘤样分化，约占整个腹膜后肿块的90%。除了介绍相关的影像学、组织病理学和免疫组织化学结果外，本文还简要讨论了腹膜后骨化/钙化肿块的主要鉴别诊断，这些肿块可能在小活检或影像学中引起诊断问题。
Sarcomatoid change in renal cell carcinoma is the result of the dedifferentiation of the "parent" tumor into a high-grade malignancy characterized by sarcoma-like features and associated with an accelerated clinical course and poorer prognosis. Any of the renal cell carcinoma subtypes can undergo sarcomatoid dedifferentiation, with the chromophobe variant being the most prone. The present report describes the case of a woman affected by a classic chromophobe renal cell carcinoma that developed dedifferentiation accompanied by a very rare osteosarcoma-like divergent differentiation, which constituted about 90% of the entire retroperitoneal mass. In addition to presenting the relevant imaging, histopathological, and immunohistochemical findings, this article briefly discusses the main differential diagnosis of retroperitoneal ossifying/calcifying masses, which could give rise to diagnostic problems either in small biopsies or at imaging.