Trophic factors therapy in Parkinson's disease.
Trophic factors therapy in Parkinson's disease.
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DOI：
10.1016/s0079-6123(09)17514-3
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发表时间：
2009
影响因子：
--
通讯作者：
Kordower, Jeffrey H.
中科院分区：
文献类型：
--
作者：
Ramaswamy, Shilpa;Soderstrom, Katherine E.;Kordower, Jeffrey H.
关键词：
帕金森病 (PD) 是一种进行性神经退行性疾病，目前尚无有效的神经保护疗法。患者通常接受药物疗法的组合治疗和/或接受深部脑刺激以对抗行为症状。理想的候选疗法是预防大脑神经退行性变的疗法，从而阻止衰弱疾病症状的进展。神经营养因子一直处于 PD 研究的前沿，并且已经使用 GDNF 配体家族 (GFL) 的成员启动了临床试验。 GFL 已被证明对腹侧中脑细胞具有营养作用，从而使其成为 PD 研究的良好候选者。本文探讨了 GFL 的两个成员 GDNF 和 neurturin 在 PD 动物模型和临床试验中的使用。
Parkinson’s disease (PD) is a progressive, neurodegenerative disorder for which there is currently no effective neuroprotective therapy. Patients are typically treated with a combination of drug therapies and/or receive deep brain stimulation to combat behavioral symptoms. The ideal candidate therapy would be the one which prevents neurodegeneration in the brain, thereby halting the progression of debilitating disease symptoms. Neurotrophic factors have been in the forefront of PD research, and clinical trials have been initiated using members of the GDNF family of ligands (GFLs). GFLs have been shown to be trophic to ventral mesencephalic cells, thereby making them good candidates for PD research. This paper examines the use of GDNF and neurturin, two members of the GFL, in both animal models of PD and clinical trials.