CAFFEINE USE DURING PREGNANCY AND CHILD OUTCOME - A 7-YEAR PROSPECTIVE-STUDY
CAFFEINE USE DURING PREGNANCY AND CHILD OUTCOME - A 7-YEAR PROSPECTIVE-STUDY
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DOI：
10.1016/0892-0362(91)90093-c
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发表时间：
1991-07-01
影响因子：
2.9
通讯作者：
STREISSGUTH, AP
中科院分区：
文献类型：
--
作者：
BARR, HM;STREISSGUTH, AP
咖啡因（来自1974-75年采访的1529名孕妇的咖啡、茶、可乐和/或摄入的药物）。产前咖啡因对妊娠结局和后代发育的线性和阈值效应在约500个后代的队列中进行了检查。对相关协变量（吸烟、饮酒、母体体型、人口统计学等）进行适当的统计学调整后，产前咖啡因暴露与大多数新生儿和婴儿结局指标（包括身高、体重或头围）或7岁时单独进行的智商和注意力测试无关。只有一个孤立的因变量与产前咖啡因暴露显着相关：即臀位。然而，由于本报告涉及对为其他目的收集的数据进行的二次分析，因此需要专门设计的研究来确定观察到的任何特定变量的相关性的有效性。一般的结论是，产前咖啡因在这个队列中的长期后果是零。
Caffeine (from coffee, tea, cola, and/or ingested drug among 1529 pregnant women interviewed in 1974-75. Linear and threshold effects of prenatal caffeine on pregnancy outcome and offspring development were examined in a cohort of approximately 500 offspring. After appropriate statistical adjustment for relevant covariates (cigarette smoking, alcohol, maternal size, demographics, etc.) prenatal caffeine exposure was not related to most newborn and infant outcome measures, including height, weight or head circumference, or to individually administered IQ and attention tests at 7 years of age. Only one isolated dependent variable of the many was significantly associated with prenatal caffeine exposure: namely breech presentation. However, since this report involved a secondary analysis of data gathered for other purposes, specifically designed studies would be required to determine the validity of the observed association for any particular variable. The general conclusion is that the long-term consequences of prenatal caffeine in this cohort are null.