Combination implementation for HIV prevention: moving from clinical trial evidence to population-level effects.
Combination implementation for HIV prevention: moving from clinical trial evidence to population-level effects.
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DOI：
10.1016/s1473-3099(12)70273-6
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发表时间：
2013-01
影响因子：
56.3
通讯作者：
Reynolds, Steven J.
中科院分区：
文献类型：
--
作者：
Chang, Larry W.;Serwadda, David;Quinn, Thomas C.;Wawer, Maria J.;Gray, Ronald H.;Reynolds, Steven J.
联合预防艾滋病毒-应用多种艾滋病毒预防干预措施以最大限度地扩大人口影响-的前景从未如此之大。然而，为了成功地实现艾滋病毒发病率的大幅下降，还需要考虑一个额外的概念-综合实施。在此，艾滋病毒预防的综合实施被定义为务实、本地化地应用循证战略，以实现艾滋病毒预防干预措施的高持续吸收和质量。本综述探讨了不同的实施策略，包括艾滋病毒检测和咨询模式，任务转移，联系和保留护理，抗逆转录病毒治疗支持，行为改变，需求创造，和结构性干预措施，并讨论了如何将其用于提供艾滋病毒预防干预措施，如医疗男性包皮环切术和治疗作为预防。只有认真考虑如何实施和操作艾滋病毒预防干预措施，艾滋病毒界才能从临床试验证据转向人口一级的影响。
The promise of combination HIV prevention—the application of multiple HIV prevention interventions to maximize population-level impact—has never been greater. However, to succeed in achieving significant reductions in HIV incidence, an additional concept needs to be considered—combination implementation. Combination implementation for HIV prevention is defined here as the pragmatic, localized application of evidence-based strategies to realize high sustained uptake and quality of HIV prevention interventions. This review explores diverse implementation strategies including HIV testing and counseling models, task shifting, linkage to and retention in care, antiretroviral therapy support, behavior change, demand creation, and structural interventions and discusses how they could be used in the provision of HIV prevention interventions such as medical male circumcision and treatment as prevention. Only through careful consideration of how to implement and operationalize HIV prevention interventions will the HIV community be able to move from clinical trial evidence to population-level impact.