Preoperative chemotherapy for unresectable primary hepatic malignancies in children.
Preoperative chemotherapy for unresectable primary hepatic malignancies in children.
复制标题
儿童不可切除的原发性肝恶性肿瘤的术前化疗。
DOI：
10.1002/1097-0142(19820915)50:6
复制
发表时间：
1982
期刊：
影响因子：
6.2
通讯作者：
Weitzman,JJ
中科院分区：
文献类型：
--
作者：
Weinblatt,ME;Siegel,SE;Siegel,MM;Stanley,P;Weitzman,JJ
8名儿童呈现不可切除的原发性肝脏恶性肿瘤治疗化疗，试图减少肿瘤的大小。阿霉素用于所有药物方案，通常与环磷酰胺、长春新碱和5 -氟尿嘧啶联合使用。7名儿童表现出明显的临床反应，原发肿瘤的大小明显减少，任何肺转移灶都存在。四名儿童能够进行完整、简单的手术切除残余疾病，三名儿童存活并接受了良好的治疗。1例肝癌患者经单纯化疗后全部疾病完全消失。广泛肝恶性肿瘤术前化疗的方法可能允许最终切除最初无法手术的病变，并为这些高致命性恶性肿瘤提供长期生存。
Eight children presenting with unresectable primary hepatic malignancies were treated with chemotherapy in an attempt to decrease the size of the tumor. Adriamycin was used in all drug regimens, usually in combination with cyclophosphamide, vincristine, and 5‐fluorouracil. Seven children exhibited a pronounced, clinical response with marked reduction in the size of the primary tumor as well as any pulmonary metastases present. Four children were able to have complete, uncomplicated surgical excision of residual disease, and three are alive and well off therapy. One patient with hepatocellular carcinoma had complete disappearance of all disease with chemotherapy alone. An approach utilizing preoperative chemotherapy for extensive hepatic malignancies may permit eventual resection of initially inoperable lesions, with long‐term survival for these highly lethal malignancies.