Detection of polymorphisms in the prion protein gene in a population of Irish Suffolk sheep
Detection of polymorphisms in the prion protein gene in a population of Irish Suffolk sheep
复制标题
爱尔兰萨福克羊朊病毒蛋白基因多态性检测
DOI：
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发表时间：
2000
期刊：
影响因子：
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通讯作者：
N. Hunter
中科院分区：
文献类型：
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作者：
E. O'Doherty;M. Aherne;S. Ennis;J. Roche;T. Sweeney;E. Weavers;N. Hunter
自然瘙痒症与朊病毒蛋白（PrP）基因多态性有关。在Suffolks中，密码子171是发现最多变异的密码子; RR 171被认为与发展疾病临床体征的抗性相关，而QQ 171与疾病易感性相关。本研究的目的是首先确定在爱尔兰的萨福克公羊的PrP基因型，其次比较公羊羔羊的基因型谱从羊群的基础上的基因型AA 136 RR 154 RR 171的育种计划已经启动，从羊群没有育种计划的基础上PrP基因型。在爱尔兰人群中进行基因分型的公羊中，大约13%在遗传上容易出现该疾病的临床症状。然而，来自在过去一年中启动了RR 171选择性育种策略的农场的羔羊比来自未应用育种策略的农场的储备公羊或公羊羔羊具有更大比例的RR 171和更小比例的QQ 171。
Natural scrapie is associated with polymorphisms in the prion protein (PrP) gene. In Suffolks, codon 171 is the codon at which most variation is found; RR171 is thought to be associated with resistance to developing the clinical signs of the disease and QQ171 is associated with susceptibility to the disease. The objectives of this study were first to determine the PrP genotypes of Suffolk stock rams in Ireland, and secondly to compare the genotype profiles of ram lambs from flocks where a breeding programme based on the genotype AA136RR154RR171 had been initiated and from flocks where there was no breeding programme based on PrP genotype. Approximately 13 per cent of the stock rams genotyped in the Irish population were genetically susceptible to showing the clinical signs of the disease. However, lambs from farms that had initiated a selective breeding strategy for RR171 over the past year had a larger proportion of RR171 and a smaller proportion of QQ171 than the stock rams or ram lambs from farms not applying a breeding strategy.
影响因子：
10.5
作者：
D. Westaway;V. Zuliani;C. Cooper;M. Da Costa;S. Neuman;A L Jenny;L. Detwiler;S. B. Prusiner
通讯作者：
D. Westaway;V. Zuliani;C. Cooper;M. Da Costa;S. Neuman;A L Jenny;L. Detwiler;S. B. Prusiner