Adult heart transplantation with distant procurement and ex-vivo preservation of donor hearts after circulatory death: a case series
Adult heart transplantation with distant procurement and ex-vivo preservation of donor hearts after circulatory death: a case series
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DOI：
10.1016/s0140-6736(15)60038-1
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发表时间：
2015-06-27
期刊：
影响因子：
168.9
通讯作者：
Macdonald, Peter
中科院分区：
文献类型：
--
作者：
Dhital, Kumud K.;Iyer, Arjun;Macdonald, Peter
背景：原位心脏移植是治疗药物难治性终末期心力衰竭的金标准。然而，合适的心脏供体是稀缺的。虽然循环死亡后的捐赠已用于肾、肝和肺移植，但不用于心脏移植。我们报告的情况下，一系列的心脏移植供体循环dead.Methods受体的患者在圣文森特医院，悉尼，澳大利亚。他们接受了年龄小于40岁的循环性死亡后捐赠的马斯特里赫特III类受控心脏，最大热缺血时间为30分钟。我们通过补充心脏停搏液的初始心肌保护回收了4颗心脏，并转移到器官护理系统（Transmedics）保存，复苏，并运送到收件人医院。（2男1女;平均年龄52岁），低经颅压差（
Background Orthotopic heart transplantation is the gold-standard long-term treatment for medically refractive endstage heart failure. However, suitable cardiac donors are scarce. Although donation after circulatory death has been used for kidney, liver, and lung transplantation, it is not used for heart transplantation. We report a case series of heart transplantations from donors after circulatory death.Methods The recipients were patients at St Vincent's Hospital, Sydney, Australia. They received Maastricht category III controlled hearts donated after circulatory death from people younger than 40 years and with a maximum warm ischaemic time of 30 min. We retrieved four hearts through initial myocardial protection with supplemented cardioplegia and transferred to an Organ Care System (Transmedics) for preservation, resuscitation, and transportation to the recipient hospital.Findings Three recipients (two men, one woman; mean age 52 years) with low transpulmonary gradients (