Similarities in Clinical and Psychosocial Characteristics of Functional Diarrhea and Irritable Bowel Syndrome With Diarrhea.
Similarities in Clinical and Psychosocial Characteristics of Functional Diarrhea and Irritable Bowel Syndrome With Diarrhea.
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功能性腹泻和腹泻性肠易激综合征的临床和心理社会特征的相似性。
DOI：
10.1016/j.cgh.2019.08.020
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
Lembo,Anthony
中科院分区：
文献类型：
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作者：
Singh,Prashant;Lee,Ha-Neul;Rangan,Vikram;Ballou,Sarah;Lembo,Joseph;Katon,Jesse;McMahon,Courtney;Friedlander,Daniel;Iturrino,Johanna;Nee,Judy;Lembo,Anthony
背景与目的关于功能性腹泻（FDr）患者的临床和心理特征的研究很少。我们研究了与FDr提出的三级保健诊所的患者的临床和心理特征，并比较了症状的FDr与IBS腹泻（IBS-D）的轮廓。MethodsConcretive患者诊断FDr（n = 48）或IBS-D（n = 49），每罗马IV标准，完成了详细的症状调查，从2017年10月至2018年7月。腹痛和腹泻的严重程度进行了评估，使用患者报告的结果测量信息系统（PROMIS）问卷。根据PROMIS T评分60分或以上确定焦虑、抑郁或睡眠障碍患者。平均值和比例进行了比较，使用Studentttest和卡方analysis.ResultsA明显较低的比例与FDR患者报告腹痛（77.1%）比IBS-D患者（100%，P <0.001）。报告腹胀的患者比例和严重程度在两组之间没有显著差异。两组腹泻患者的排便比例无显著差异（P= .54），但IBS-D患者的平均腹泻PROMIS T评分显著较高（P= .03）。这一差异是由于IBS-D患者报告的粪便尿急相关痛苦水平显著较高所致（P= .007）。焦虑，抑郁，或睡眠障碍，其严重程度，患者的比例，并没有显着groups.ConclusionsIn约100例FDR或IBS-D的分析，我们发现重叠的胃肠道和心身症状。这两个实体似乎是一个连续体。
Background & AimsThere have been few published studies of clinical and psychological characteristics of patients with functional diarrhea (FDr). We studied the clinical and psychological characteristics of patients with FDr presenting to a tertiary care clinic, and compared symptom profiles of FDr with those of IBS-diarrhea (IBS-D).MethodsConsecutive patients with a diagnosis of FDr (n = 48) or IBS-D (n = 49), per Rome IV criteria, completed a detailed symptom survey from October 2017 through July 2018. Abdominal pain and diarrhea severity were assessed using patient-reported outcomes measurement information system (PROMIS) questionnaires. Patients with anxiety, depression, or sleep disturbances were identified based on PROMIS T-score of 60 or more. Mean and proportions were compared using the Studentttest and chi-square analyses, respectively.ResultsA significantly lower proportion of patients with FDr reported abdominal pain (77.1%) than patients with IBS-D (100%,P< .001). The proportion of patients reporting abdominal bloating and level of severity did not differ significantly between groups. Proportions of bowel movements with diarrhea did not differ significantly between groups (P= .54), but the mean diarrhea PROMIS T-score was significantly higher among patients with IBS-D (P= .03). This difference resulted from the significantly higher levels of fecal urgency-related distress reported by patients with IBS-D (P= .007). Proportions of patients with anxiety, depression, or sleep disturbance, and their severities, did not differ significantly between groups.ConclusionsIn an analysis of about 100 patients with FDr or IBS-D, we found overlap in gastrointestinal and psychosomatic symptoms. These 2 entities appear to be a continuum.