Evaluation and characterization of the hypothyroid hyt/hyt mouse. I: Somatic and behavioral studies.
Evaluation and characterization of the hypothyroid hyt/hyt mouse. I: Somatic and behavioral studies.
复制标题
甲状腺功能减退 hyt/hyt 小鼠的评估和表征。
DOI：
10.1159/000125105
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发表时间：
1989
影响因子：
4.1
通讯作者：
Shanklin,DR
中科院分区：
文献类型：
--
作者：
Adams,PM;Stein,SA;Palnitkar,M;Anthony,A;Gerrity,L;Shanklin,DR
常染色体隐性基因甲状腺功能减退 (hyt) 纯合子小鼠在受孕 15 天后，胎儿就患有先天性甲状腺功能减退症。 Neonatalhyt/hytmice 的血清甲状腺素降低了正常值的 1/5 至 1/6，并且躯体和行为发育显着延迟。躯体发育迟缓包括睁眼和竖耳迟缓，以及体长和体重减少。与正常同窝动物相比，Thehyt/hytan 动物表现出延迟的反射行为以及异常的运动和适应性行为。即使没有 T4 测定，体细胞和行为测量也可以清楚地将 hyt/hytan 动物与其正常同窝动物区分开来。 thehyt/hytmouse 的躯体和反射行为异常与人类先天性甲状腺功能减退症的其他啮齿动物模型相似。 Thehyt/hytmouse 为探索与胎儿自主甲状腺功能缺陷相关的严重原发性遗传性甲状腺功能减退症的影响提供了理想的模型，并且与子宫内和新生儿早期甲状腺激素缺乏显着改变功能发育的假设一致。
Mice homozygous for the autosomal-recessive gene hypothyroid (hyt) had congenital hypothyroidism of fetal onset after 15 days postconception. Neonatalhyt/hytmice had reduced serum thyroxine ranging from 1/5 to 1/6 of normal as well as significantly delayed somatic and behavioral development. Delayed somatic development included retarded eye opening and ear raising, and reduced body length and body weight. Thehyt/hytanimals compared to their normal littermates demonstrated delayed reflexive behavior and abnormal motor and adaptive behavior. The somatic and behavioral measures clearly distinguishedhyt/hytanimals from their normal littermates even without T4 determination. The somatic and reflexive behavioral abnormalities in thehyt/hytmouse were similar to other rodent models of human congenital hypothyroidism. Thehyt/hytmouse provided an ideal model for exploring the effect of severe primary inherited hypothyroidism related to deficient autonomous fetal thyroid function and was consistent with the hypothesis that thyroid hormone deficit in utero and in the early neonatal period significantly altered functional development.