Plasma brain natriuretic peptide concentration: Impact of age and gender
Plasma brain natriuretic peptide concentration: Impact of age and gender
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DOI：
10.1016/s0735-1097(02)02059-4
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发表时间：
2002-09-04
影响因子：
24
通讯作者：
Burnett, JC
中科院分区：
文献类型：
--
作者：
Redfield, MM;Rodeheffer, RJ;Burnett, JC
我们希望在一项以人群为基础的研究中检测年龄和性别对血浆脑钠尿肽（BNP）浓度的影响。背景BNP浓度的测量被批准用于心力衰竭的诊断，并可能有助于检测左心室功能障碍。虽然BNP已被批准用于临床，但关于在无心血管疾病或心功能不全的人群中观察到的BNP范围的数据很少。这些数据是必不可少的解释BNP.METHODS在2,042随机选择的居民Olmsted县，明尼苏达州，>44岁，BNP（Shionogi和Biosite测定），多普勒超声心动图，并进行医疗记录审查。一个正常的子集的主题（n = 767）在窦性心律没有心血管，肾脏，或肺部疾病或糖尿病，对没有心血管药物，并与正常的收缩，舒张和瓣膜功能被identified.RESULTS在正常的子集，BNP的分布不同的年龄，性别和检测系统。使用这两种检测试剂盒，BNP随年龄增长而显著增加，女性显著高于男性，导致年龄，性别和检测试剂盒特异性参考范围。在整个队列的每个年龄/性别分层中进行BNP检测射血分数小于或等于40%的能力的受试者操作特征分析（n = 2，（第042号）并证实BNP检测射血分数降低的判别值在女性和老年人中更高，并且两种检测方法之间存在差异。年龄、性别和测定特异性分区值。
OBJECTIVES We wished to examine the effects of age and gender on plasma brain natriurctic peptide (BNP) concentration in a population-based study.BACKGROUND Measurement of BNP concentration is approved for use in the diagnosis of heart failure and may aid in the detection of left ventricular dysfunction. Although BNP is approved for clinical use, there are few data regarding the range of BNP observed in persons without cardiovascular disease or cardiac dysfunction. These data are essential for the interpretation of BNP.METHODS In 2,042 randomly selected residents of Olmsted County, Minnesota, >44 years old, BNP (Shionogi and Biosite assays), Doppler echocardiography, and medical record review were performed. A normal subset of subjects (n = 767) in sinus rhythm without cardiovascular, renal, or pulmonary disease or diabetes; on no cardiovascular medications; and with normal systolic, diastolic, and valvular function was identified.RESULTS Within the normal subset, the distribution of BNP differed by age, gender, and assay system. With both assays, BNP increased significantly with age and was significantly higher in women than men, leading to age-, gender-, and assay-specific reference ranges. Receiver operating characteristic analysis for the ability of BNP to detect an ejection fraction less than or equal to40% was performed in each age/gender stratum in the entire cohort (n = 2,042) and confirmed that discriminatory values for BNP for detection of reduced ejection fraction were higher in women and older persons and were different between the two assays.CONCLUSIONS Interpretation of BNP should include consideration of age-, gender-, and assay-specific partition values.