Oscillating gradient diffusion kurtosis imaging of normal and injured mouse brains.
Oscillating gradient diffusion kurtosis imaging of normal and injured mouse brains.
复制标题
正常和受伤小鼠大脑的振荡梯度扩散峰度成像。
DOI：
10.1002/nbm.3917
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发表时间：
2018
影响因子：
2.9
通讯作者：
Zhang,Jiangyang
中科院分区：
文献类型：
--
作者：
Wu,Dan;Li,Qiang;Northington,FrancesJ;Zhang,Jiangyang
扩散MRI的最新进展采用具有不同扩散方向、权重和扩散时间的多个扩散编码方案来研究生物组织中的特定微结构特性。在这项研究中，我们检查了成年小鼠脑和新生小鼠脑缺氧缺血（HI）损伤后的时间依赖性弥散峰度对比度。在体内弥散峰度图使用100 Hz振荡梯度自旋回波（OGSE）序列在短弥散时间内获得，使用脉冲梯度自旋回波（PGSE）序列在相对较长的弥散时间（20 ms）内获得。在成年小鼠脑中，我们发现，皮质和海马表现出更大的差异OGSE峰度和PGSE峰度比主要的白色物质束。在单侧HI损伤的新生小鼠脑中，OGSE峰度图总体上提供了比PGSE峰度图更强的水肿对比，并且水肿区域中OGSE和PGSE峰度测量之间的差异反映了损伤的异质性。这是第一个证明小鼠大脑中多方向OGSE峰度对比的体内研究。比较PGSE和OGSE峰度指标可能提供缺血性卒中后微结构变化的额外信息。
Recent advances in diffusion MRI employ multiple diffusion encoding schemes with varying diffusion direction, weighting, and diffusion time to investigate specific microstructural properties in biological tissues. In this study, we examined time‐dependent diffusion kurtosis contrast in adult mouse brains and in neonatal mouse brains after hypoxic–ischemic (HI) injury.In vivodiffusion kurtosis maps were acquired with a short diffusion time using an oscillating gradient spin echo (OGSE) sequence at 100 Hz and with a relatively long diffusion time (20 ms) using a pulsed gradient spin echo (PGSE) sequence. In the adult mouse brain, we found that the cortex and hippocampus showed larger differences between OGSE kurtosis and PGSE kurtosis than major white matter tracts. In neonatal mouse brains with unilateral HI injury, the OGSE kurtosis map overall provided stronger edema contrast than the PGSE kurtosis map, and the differences between OGSE and PGSE kurtosis measurements in the edema region reflected heterogeneity of injury. This is the firstin vivostudy that has demonstrated multi‐direction OGSE kurtosis contrasts in the mouse brain. Comparing PGSE and OGSE kurtosis measures may provide additional information on microstructural changes after ischemic stroke.