Composition and structure of articular cartilage - A template for tissue repair
Composition and structure of articular cartilage - A template for tissue repair
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DOI：
10.1097/00003086-200110001-00004
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发表时间：
2001-10-01
影响因子：
4.2
通讯作者：
Laverty, S
中科院分区：
文献类型：
--
作者：
Poole, AR;Kojima, T;Laverty, S
作者对关节软骨的结构和组成进行了综述。这个组织是由软骨细胞合成的广泛的细胞外基质组成的。它从关节表面到关节表面的深度不同，在软骨细胞周围有一个区域性的组织。它的成分在胶原和蛋白多糖以及其他基质分子的含量上存在区域和地带性差异。有一个大纤维胶原网络和一个微丝网络，其他非胶原分子围绕着这个网络组织。它的结构和组成反映了它的特殊机械性能，主要反映了它的抗拉强度(胶原蛋白)和压缩硬度(蛋白多糖)以及细胞与基质的相互作用(非胶原蛋白)。
The authors review the structure and composition of articular cartilage. This tissue is composed of an extensive extracellular matrix synthesized by chondrocytes. It contains different zones with respect to depth from the articular surface and has a regional organization around the chondrocytes. Its composition varies regionally and zonally in its collagen and proteoglycan contents and those of other matrix molecules. There is a macrofibrillar collagen network and a microfilamentous network about which other noncollagenous molecules are organized. Its structure and composition are reflective of its special mechanical properties that primarily reflect its tensile strength (collagens) and compressive stiffness (proteoglycan aggrecan) and cell-matrix interactions (noncollagenous proteins).