Methodological Standards and Patient-Centeredness in Comparative Effectiveness Research The PCORI Perspective
Methodological Standards and Patient-Centeredness in Comparative Effectiveness Research The PCORI Perspective
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DOI：
10.1001/jama.2012.466
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发表时间：
2012-04-18
影响因子：
120.7
通讯作者：
Yancy, Clyde
中科院分区：
文献类型：
--
作者：
Basch, Ethan;Aronson, Naomi;Yancy, Clyde
严格的方法标准有助于确保医学研究产生有效且可推广的信息，并且对于以患者为中心的结果研究（PCOR）至关重要。以患者为中心是指患者的偏好、决策需求和特征得到解决的程度，是变革和组织振兴方案区别于比较有效性研究的关键特征。2010年签署成为法律的《患者保护和平价医疗法案》创建了以患者为中心的成果研究所（PCRI），其中包括一个独立的联邦任命的方法委员会。方法委员会负责为变革和组织振兴方案制定方法标准。该委员会确定的4个一般领域将制定标准：（1）优先考虑研究问题，（2）使用适当的研究设计和分析，（3）在整个研究过程中纳入患者的观点，（4）促进有效的传播和实施结果。国会授权的PCORI方法报告（将于2012年5月发布第一次迭代）将开始提供这些领域的标准，并将为未来PCORI的供资公告和审查标准提供信息。方法委员会的工作旨在生成与患者相关且值得信赖的信息，并做出改善以患者为中心的结局的决策。美国医学会杂志2012;307（15）：1636-1640 www.jama.com
Rigorous methodological standards help to ensure that medical research produces information that is valid and generalizable, and are essential in patient-centered outcomes research (PCOR). Patient-centeredness refers to the extent to which the preferences, decision-making needs, and characteristics of patients are addressed, and is the key characteristic differentiating PCOR from comparative effectiveness research. The Patient Protection and Affordable Care Act signed into law in 2010 created the Patient-Centered Outcomes Research Institute (PCORI), which includes an independent, federally appointed Methodology Committee. The Methodology Committee is charged to develop methodological standards for PCOR. The 4 general areas identified by the committee in which standards will be developed are (1) prioritizing research questions, (2) using appropriate study designs and analyses, (3) incorporating patient perspectives throughout the research continuum, and (4) fostering efficient dissemination and implementation of results. A Congressionally mandated PCORI methodology report (to be issued in its first iteration in May 2012) will begin to provide standards in each of these areas, and will inform future PCORI funding announcements and review criteria. The work of the Methodology Committee is intended to enable generation of information that is relevant and trustworthy for patients, and to enable decisions that improve patient-centered outcomes. JAMA. 2012;307(15):1636-1640 www.jama.com