Progressive alignment of inhibitory and excitatory delay may drive a rapid developmental switch in cortical network dynamics.
Progressive alignment of inhibitory and excitatory delay may drive a rapid developmental switch in cortical network dynamics.
复制标题
抑制性延迟和兴奋性延迟的逐步协调可能会驱动皮质网络动力学的快速发育转换。
DOI：
10.1152/jn.00402.2019
复制
发表时间：
2020
影响因子：
2.5
通讯作者：
Gutkin,BorisS
中科院分区：
文献类型：
--
作者：
Romagnoni,Alberto;Colonnese,MatthewT;Touboul,JonathanD;Gutkin,BorisS
神经系统的成熟发生在多个层面上--突触、回路和网络--在不同的时间尺度上。例如，许多突触特性逐渐成熟，而新兴的网络动态可能会突然改变。在这里，我们结合实验和理论方法来研究视觉发育所必需的自发和感官诱发的丘脑皮质活动的突然转变。受体内突触电流时间尺度和幅度测量的启发，我们扩展了Wilson和Cowan模型，以考虑抑制性和兴奋性神经群体反应的相对起始时间和幅度。我们研究这个系统，因为这些参数在与发育观察一致的幅度和时间尺度内变化，以识别可能解释活体网络行为的动力学分支。我们的发现表明，抑制时间是丘脑皮质活动成熟的关键决定因素；抑制时间与兴奋开始时间比率的逐渐衰减驱动系统通过一个分叉，导致网络自发活动从高幅度振荡到非振荡活跃状态的突然切换。这一开关还推动了从阈值爆发到对瞬时刺激的线性反应的变化，这也与活体观察一致。因此，我们表明抑制计时可能对网络动力学的发展至关重要，并且可能是活动快速变化的基础，而潜在的突触和细胞参数没有类似的快速变化。NEW&NOTEWORTHY依赖于Wilson-Cowan模型的推广，该模型为理解抑制成熟和网络动力学之间的联系提供了坚实的分析基础，我们提出了一种潜在的解释，解释了在视觉开始之前，兴奋性/抑制性突触延迟在调节丘脑皮质视觉活动突然切换中的作用。
Nervous system maturation occurs on multiple levels—synaptic, circuit, and network—at divergent timescales. For example, many synaptic properties mature gradually, whereas emergent network dynamics can change abruptly. Here we combine experimental and theoretical approaches to investigate a sudden transition in spontaneous and sensory evoked thalamocortical activity necessary for the development of vision. Inspired by in vivo measurements of timescales and amplitudes of synaptic currents, we extend the Wilson and Cowan model to take into account the relative onset timing and amplitudes of inhibitory and excitatory neural population responses. We study this system as these parameters are varied within amplitudes and timescales consistent with developmental observations to identify the bifurcations of the dynamics that might explain the network behaviors in vivo. Our findings indicate that the inhibitory timing is a critical determinant of thalamocortical activity maturation; a gradual decay of the ratio of inhibitory to excitatory onset time drives the system through a bifurcation that leads to a sudden switch of the network spontaneous activity from high-amplitude oscillations to a nonoscillatory active state. This switch also drives a change from a threshold bursting to linear response to transient stimuli, also consistent with in vivo observation. Thus we show that inhibitory timing is likely critical to the development of network dynamics and may underlie rapid changes in activity without similarly rapid changes in the underlying synaptic and cellular parameters.NEW & NOTEWORTHYRelying on a generalization of the Wilson–Cowan model, which allows a solid analytic foundation for the understanding of the link between maturation of inhibition and network dynamics, we propose a potential explanation for the role of developing excitatory/inhibitory synaptic delays in mediating a sudden switch in thalamocortical visual activity preceding vision onset.
α-骨骼和α-心脏肌动蛋白基因在成人骨骼肌和心脏中共表达
影响因子：
5.3
作者：
P. Gunning;P. Ponte;H. Blau;L. Kedes
通讯作者：
L. Kedes