Parenthood probability and pregnancy outcome in patients with a cancer diagnosis during adolescence and young adulthood
Parenthood probability and pregnancy outcome in patients with a cancer diagnosis during adolescence and young adulthood
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DOI：
10.1093/humrep/dem362
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发表时间：
2008-01-01
影响因子：
6.1
通讯作者：
Fossa, S. D.
中科院分区：
文献类型：
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作者：
Magelssen, H.;Melve, K. K.;Fossa, S. D.
背景：比较癌症患者和普通人群的首次生育概率和妊娠结局。方法：来自诊断时年龄在15-35岁的癌症患者的医院登记处的数据，包括诊断日期/类型，治疗和死亡日期，与来自癌症登记处和医学出生登记处的数据合并，提供分娩日期，IVF，妊娠结局和人口统计学。研究结果：男性患者（n = 463）和男性一般人群（n = 367 068）在35岁时首次生育的概率分别为63%和64%。女性患者的数字为66%（n = 284），而女性一般人群为79%（n = 349 576）（P = 0.007）。共有487名男性和251名女性癌症患者在诊断前没有孩子，130名男性和104名女性癌症患者在诊断前有一个孩子，诊断后至少有一个孩子。先天性畸形在首次生育至既往无子女的男性患者中更常见[校正比值比（ORadj）：1.5; 95%置信区间（CI）：1.1-2.3]。女性患者所生婴儿的低出生体重和癌症后早产的风险增加，诊断后第一胎的围产期死亡率（ORadj 2.3; 95% CI：1.1-5.0）也增加。结论：35岁癌症患者的首次生育概率接近60%，女性患者的首次生育概率与一般人群相比显著降低。女性患者诊断后怀孕是高危妊娠。
BACKGROUND: To compare first-time parenthood probability and pregnancy outcome between cancer patients and the general population. METHODS: Data from a hospital registry on cancer patients aged 15-35 years at diagnosis, including date/type of diagnosis, treatment and date of death, were merged with data from the Cancer Registry and the Medical Birth Registry, providing date of childbirth, IVF, pregnancy outcomes and demographics. RESULTS: The first-time parenthood probability at the age of 35 years was 63% in male patients (n = 463) and 64% in the male general population (n = 367 068). Figures in female patients were 66% (n = 284) compared with 79% in the female general population (n = 349 576) (P = 0.007). A total of 487 male and 251 female cancer patients were childless pre-diagnosis, and 130 male and 104 female cancer patients had one child before diagnosis and at least one birth post-diagnosis. Congenital anomalies were more frequent in first-borns to previously childless male patients [adjusted odds ratio (ORadj): 1.5; 95% confidence interval (CI): 1.1-2.3]. The risk of low birth weight and preterm delivery after cancer was increased in infants born to female patients, as was perinatal mortality (ORadj 2.3; 95% CI: 1.1-5.0) among post-diagnosis first births. CONCLUSIONS: The first-time parenthood probability in 35-year old cancer patients is similar to 60%, which in female patients is significantly reduced compared with the general population. Post-diagnosis pregnancies to female patients are high-risk pregnancies.