On the subspecific origin of the laboratory mouse
On the subspecific origin of the laboratory mouse
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DOI：
10.1038/ng2087
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发表时间：
2007-09-01
期刊：
影响因子：
30.8
通讯作者：
de Villena, Fernando Pardo-Manuel
中科院分区：
文献类型：
--
作者：
Yang, Hyuna;Bell, Timothy A.;de Villena, Fernando Pardo-Manuel
实验室小鼠的基因组被认为是具有不同亚种起源的区域的马赛克。我们已经开发了一个高分辨率的地图起源的实验室小鼠产生25,400系统发育树在100 kb的间隔跨越基因组。平均而言，92%的基因组是小家鼠的起源，和多样性的分布是显着的非随机的染色体。有大量多样性极低的区域，这是自然变异和复杂性状研究的盲点，也是多样性的热点。与镶嵌模型相反，我们发现大部分基因组具有亚种内起源的中等水平变异。最后，来自野生的小鼠品系，应该代表不同的小鼠亚种表现出大量的亚种间渐渗，这对进化研究有很强的影响，假设这些是一个给定的亚种的纯代表。
The genome of the laboratory mouse is thought to be a mosaic of regions with distinct subspecific origins. We have developed a high- resolution map of the origin of the laboratory mouse by generating 25,400 phylogenetic trees at 100- kb intervals spanning the genome. On average, 92% of the genome is of Mus musculus domesticus origin, and the distribution of diversity is markedly nonrandom among the chromosomes. There are large regions of extremely low diversity, which represent blind spots for studies of natural variation and complex traits, and hot spots of diversity. In contrast with the mosaic model, we found that most of the genome has intermediate levels of variation of intrasubspecific origin. Finally, mouse strains derived from the wild that are supposed to represent different mouse subspecies show substantial intersubspecific introgression, which has strong implications for evolutionary studies that assume these are pure representatives of a given subspecies.