The pattern of Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive epidemiological analysis of data from the Saudi Ministry of Health.
The pattern of Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive epidemiological analysis of data from the Saudi Ministry of Health.
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DOI：
10.2147/ijgm.s67061
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发表时间：
2014
影响因子：
2.3
通讯作者：
El-Sheemy MA
中科院分区：
文献类型：
--
作者：
Alghamdi IG;Hussain II;Almalki SS;Alghamdi MS;Alghamdi MM;El-Sheemy MA
本研究描述了沙特阿拉伯中东呼吸综合征冠状病毒（MERS-CoV）的流行病学。对沙特卫生部2013年6月6日至2014年5月14日期间记录的所有中东呼吸综合征冠状病毒病例数据进行流行病学分析。病例和死亡频率按月份、性别、年龄组和地区进行计算和调整。还计算了疫区全年的月平均气温和湿度。研究期间共记录了 425 例病例。病例和死亡人数最高发生在2014年4月至5月期间。男性发病率（260例[62%]）高于女性（162例[38%]），病死率男性（52%）高于女性（23%）。此外，45-59岁和≥60岁年龄组是最容易感染的人群，这些人群的病死率高于其他人群。利雅得报告的病例和死亡人数最多（169 例；43 例死亡），其次是吉达（156 例；36 例死亡）和东部地区（24 例；22 例死亡）。病死率最高的是东部地区（92%），其次是麦地那（36%）和奈季兰（33%）。 MERS-CoV 感染在相对湿度较低（<20%）和高温（15°C–35°C）的环境中会主动引发疾病。中东呼吸综合征冠状病毒被认为是沙特阿拉伯的流行病。男性的病例和死亡频率高于女性，45 岁以上的人群受影响最严重。相对湿度低和温度高会增强这种疾病在整个人群中的传播。需要进一步的分析研究来确定沙特阿拉伯的感染源和模式。
This study describes the epidemiology of Middle East respiratory syndrome coronavirus (MERS-CoV) in Saudi Arabia. Epidemiological analysis was performed on data from all MERS-CoV cases recorded by the Saudi Ministry of Health between June 6, 2013 and May 14, 2014. The frequency of cases and deaths was calculated and adjusted by month, sex, age group, and region. The average monthly temperature and humidity of infected regions throughout the year was also calculated. A total of 425 cases were recorded over the study period. The highest number of cases and deaths occurred between April and May 2014. Disease occurrence among men (260 cases [62%]) was higher than in women (162 cases [38%]), and the case fatality rate was higher for men (52%) than for women (23%). In addition, those in the 45–59 years and ≥60 years age groups were most likely to be infected, and the case fatality rate for these people was higher than for other groups. The highest number of cases and deaths were reported in Riyadh (169 cases; 43 deaths), followed by Jeddah (156 cases; 36 deaths) and the Eastern Region (24 cases; 22 deaths). The highest case fatality rate was in the Eastern Region (92%), followed by Medinah (36%) and Najran (33%). MERS-CoV infection actively causes disease in environments with low relative humidity (<20%) and high temperature (15°C–35°C). MERS-CoV is considered an epidemic in Saudi Arabia. The frequency of cases and deaths is higher among men than women, and those above 45 years of age are most affected. Low relative humidity and high temperature can enhance the spread of this disease in the entire population. Further analytical studies are required to determine the source and mode of infection in Saudi Arabia.