COVID-19 induces a hyperactive phenotype in circulating platelets.
COVID-19 induces a hyperactive phenotype in circulating platelets.
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COVID-19 会诱导循环血小板出现过度活跃的表型。
DOI：
10.1371/journal.pbio.3001109
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发表时间：
2021-03
期刊：
影响因子：
9.8
通讯作者：
COCOON Study investigators
中科院分区：
文献类型：
--
作者：
Comer SP;Cullivan S;Szklanna PB;Weiss L;Cullen S;Kelliher S;Smolenski A;Murphy C;Altaie H;Curran J;O'Reilly K;Cotter AG;Marsh B;Gaine S;Mallon P;McCullagh B;Moran N;Ní Áinle F;Kevane B;Maguire PB;COCOON Study investigators
2019年冠状病毒病(新冠肺炎)是由新型严重急性呼吸综合征冠状病毒2(SARS-CoV-2)引起的，迄今已影响全球3000多万人。尽管已有较高的静脉血栓栓塞率和新冠肺炎诱导的内皮功能障碍的证据，但新冠肺炎感染导致血栓形成风险增加的确切病因仍未完全阐明。因此，我们评估了重症和非重症新冠肺炎患者的临床血小板参数和循环血小板活性。对重症新冠肺炎患者(需要重症监护)、非重症患者(不需要重症监护)、没有新冠肺炎的普通内科住院患者和健康献血者的临床血液参数进行了评估。通过分泌物和特异性标志物分析评价血小板功能和活性。我们证明了常规的临床血液参数，包括平均血小板体积的增加和血小板/中性粒细胞比率的降低，与新冠肺炎入院和重症监护病房(ICU)的疾病严重程度相关。值得注意的是，新冠肺炎患者激动剂诱导的腺苷二磷酸释放是住院对照组的30-90倍，新冠肺炎患者循环中的血小板第4因子(PF4)、可溶性P-选择素(SP-选择素)和血小板生成素(TPO)水平也显著升高。本研究表明，重症与非重症新冠肺炎患者的血常规、全血细胞计数等临床实验室指标存在明显差异。此外，我们已经确定所有新冠肺炎患者都存在循环中的血小板过度活跃。这些数据表明，异常的血小板反应性可能导致了新冠肺炎的高凝状态，并证实了血小板/凝血在决定疾病的严重性和恢复路径的复杂性方面所起的作用。与SARS-CoV-2感染相关的血栓风险增加的原因尚不清楚。这项研究表明，疾病的严重程度与平均血小板体积增加和血小板/中性粒细胞比率下降有关；此外，所有新冠肺炎患者都有循环中的血小板过度活跃，激动剂诱导的腺苷二磷酸释放是对照组的30-90倍。
Coronavirus Disease 2019 (COVID-19), caused by the novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has affected over 30 million globally to date. Although high rates of venous thromboembolism and evidence of COVID-19-induced endothelial dysfunction have been reported, the precise aetiology of the increased thrombotic risk associated with COVID-19 infection remains to be fully elucidated. Therefore, we assessed clinical platelet parameters and circulating platelet activity in patients with severe and nonsevere COVID-19. An assessment of clinical blood parameters in patients with severe COVID-19 disease (requiring intensive care), patients with nonsevere disease (not requiring intensive care), general medical in-patients without COVID-19, and healthy donors was undertaken. Platelet function and activity were also assessed by secretion and specific marker analysis. We demonstrated that routine clinical blood parameters including increased mean platelet volume (MPV) and decreased platelet:neutrophil ratio are associated with disease severity in COVID-19 upon hospitalisation and intensive care unit (ICU) admission. Strikingly, agonist-induced ADP release was 30- to 90-fold higher in COVID-19 patients compared with hospitalised controls and circulating levels of platelet factor 4 (PF4), soluble P-selectin (sP-selectin), and thrombopoietin (TPO) were also significantly elevated in COVID-19. This study shows that distinct differences exist in routine full blood count and other clinical laboratory parameters between patients with severe and nonsevere COVID-19. Moreover, we have determined all COVID-19 patients possess hyperactive circulating platelets. These data suggest abnormal platelet reactivity may contribute to hypercoagulability in COVID-19 and confirms the role that platelets/clotting has in determining the severity of the disease and the complexity of the recovery path. The reason for the increased thrombotic risk associated with SARS-CoV-2 infection remains unclear. This study reveals that disease severity is associated with increased mean platelet volume and decreased platelet:neutrophil ratio; moreover, all COVID-19 patients possess hyperactive circulating platelets, with agonist-induced ADP release 30-to-90 fold higher than controls.
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影响因子：
6.7
作者：
Chao, Chiao-Hsuan;Wu, Wei-Chueh;Yeh, Trai-Ming
通讯作者：
Yeh, Trai-Ming
影响因子：
158.5
作者：
Ackermann, Maximilian;Verleden, Stijn E.;Jonigk, Danny
通讯作者：
Jonigk, Danny
DOI：
10.1111/jth.12178
发表时间：
2013-05
期刊：
Journal of thrombosis and haemostasis : JTH
影响因子：
--
作者：
Hottz ED;Oliveira MF;Nunes PC;Nogueira RM;Valls-de-Souza R;Da Poian AT;Weyrich AS;Zimmerman GA;Bozza PT;Bozza FA
通讯作者：
Bozza FA
影响因子：
15.9
作者：
Chen, Guang;Wu, Di;Ning, Qin
通讯作者：
Ning, Qin
影响因子：
158.5
作者：
Anderson, D. R.;Dunbar, M.;Vendittoli, P. -A.
通讯作者：
Vendittoli, P. -A.