Intact spatial learning following lesions of basal forebrain cholinergic neurons
Intact spatial learning following lesions of basal forebrain cholinergic neurons
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DOI：
10.1097/00001756-199605310-00019
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发表时间：
1996-05-31
期刊：
影响因子：
1.7
通讯作者：
Gallagher, M
中科院分区：
文献类型：
--
作者：
Baxter, MG;Bucci, DJ;Gallagher, M
自从发现阿尔茨海默病的基底前脑胆碱能神经变性以来，基底前脑胆碱能系统在学习和记忆中的作用引起了人们极大的兴趣。与预期相反，选择性去除投射到海马或新皮质的基底前脑胆碱能神经元并没有损害广泛用于研究海马/皮质功能的空间任务中的学习。如果胆碱能神经元通过海马和皮质处理的综合调节来促进学习和记忆，则可能需要联合去除海马和皮质胆碱能投射来产生损伤。然而，这种联合损伤并没有损害空间学习。这些数据反驳了基础前脑胆碱能缺乏在学习和记忆障碍中起着重要作用的观点。
THE role of the basal forebrain cholinergic system in learning and memory has held considerable interest since the discovery of cholinergic neurodegeneration in the basal forebrain in Alzheimer's disease. Contrary to expectation, selective removal of basal forebrain cholinergic neurons projecting to either hippocampus or neocortex fails to impair learning in a spatial task widely used to study hippocampal/cortical function. If cholinergic neurons contribute to learning and memory by integrated regulation of hippocampal and cortical processing, combined removal of hippocampal and cortical cholinergic projections might be necessary to produce impairment. However, this combined lesion failed to impair spatial learning. These data argue against the vie cv that basal forebrain cholinergic deficiency plays a prominent role in disorders of learning and memory.