CENTRAL AND PERIPHERAL ANTI-ALGESIC ACTION OF ASPIRIN-LIKE DRUGS
CENTRAL AND PERIPHERAL ANTI-ALGESIC ACTION OF ASPIRIN-LIKE DRUGS
复制标题
DOI：
10.1016/0014-2999(78)90265-0
复制
发表时间：
1978-01-01
影响因子：
5
通讯作者：
CORREA, FMA
中科院分区：
文献类型：
--
作者：
FERREIRA, SH;LORENZETTI, BB;CORREA, FMA
通过比较几种非甾体抗炎药阿司匹林、吲哚美辛、扑热息痛和非那西丁对角叉菜胶致痛觉过敏的足底和脑室作用，研究了它们的外周和中枢作用。痛觉过敏是通过Randall-Selitto试验的改进来测量的。所测试的药物在任何给药途径下都有镇痛作用。他们的脑室内给药增强了抗炎药物给药到爪子的镇痛作用。先前用角叉菜胶治疗一只爪子，减少了对侧爪子第二次注射角叉菜胶引起的水肿。相反，它对痛觉过敏的强度没有影响，但缩短了达到平台期所需的时间。前列腺素拮抗剂SC-19220[1-乙酰-2-（8-氯-10,11-二氢苯[b，F][1,4]-恶氮平-10-羰基）肼]在脑室、大鼠足部或两个部位均可显著抑制角叉菜胶引起的痛觉过敏。足底注射前列腺素E2的最大痛觉作用可通过脑室给药进一步增强。卡拉胶素痛觉过敏可能有外周和中枢成分，所使用的环加氧酶抑制剂可以通过防止前列腺素外周和/或中枢释放引起的痛觉过敏来发挥镇痛作用。
The peripheral and central effects of some non-steroid anti-inflammatory drugs, aspirin, indomethacin, paracetamol and phenacetin were studied by comparing their intraplantar and intracerebroventricular effects on hyperalgesia induced by carrageenin injected into the rat paw. Hyperalgesia was measured by a modification of the Randall-Selitto test. The agents tested had antialgesic effects when given by any route. Their intraventricular administration enhanced the antialgesic effect of anti-inflammatory drugs administered into the paw. Previous treatment of 1 paw with carrageenin reduced the edema caused by a 2nd injection of carrageenin in the contralateral paw. In contrast, it had no effect on the intensity of hyperalgesia but shortened the time necessary for it to reach a plateau. Administration of a prostaglandin antagonist (SC-19220 [1-acetyl-2-(8-chloro-10,11-dihydrobenz [b,F][1,4]-oxazepine-10-carbonyl) hydrazine]) in the cerebral ventricles, in the rat paw or in both sites, significantly inhibited the hyperalgesia evoked by carrageenin. The maximal hyperalgesic effect of intraplantar injections of prostaglandin E2 could be further enhanced by its cerebroventricular administration. Carrageenin hyperalgesia may have a peripheral and a central component and the cyclo-oxygenase inhibitors used may exert an antialgesic effect by preventing the hyperalgesia induced by a peripheral and/or central release of prostaglandins.