Progressive cerebral atrophy in multiple system atrophy
Progressive cerebral atrophy in multiple system atrophy
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DOI：
10.1016/s0022-510x(01)00692-x
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发表时间：
2002-03-30
影响因子：
4.4
通讯作者：
Hashizume, Y
中科院分区：
文献类型：
--
作者：
Konagaya, M;Konagaya, Y;Hashizume, Y
本文对9例多系统萎缩（MSA）患者的大脑半球受累的MRI表现进行了研究。发病年龄为56.4 ± 8.6（平均值± S.D.）年，首次MRI研究时的疾病持续时间为2.1 +/- 1.1年，末次研究时的疾病持续时间为9.7 +/- 2.6年，随访持续时间为7.6 +/- 2.3年。对照组为85名神经系统完整的人（60.2 ± 11.1岁）。在MRI研究中，对大脑半球、额叶、颞叶和顶枕叶的每个区域与颅内区域的比率进行了测量。在大脑、额叶和颞叶中观察到萎缩显著进展至低于正常限度。除典型的病理改变外，5例尸检显示额叶萎缩伴轻度胶质增生、轻度脱髓鞘和胶质细胞胞浆包涵体（GCI）。其中一名患者表现出明显的额叶萎缩，大脑皮质退行性变化。我们观察到大脑半球的受累，尤其是额叶。(C)2002 Elsevier Science B. V.保留所有权利。
Nine patients with multiple system atrophy (MSA) were studied based on MRI findings of cerebral hemispheric involvement. The age at onset was 56.4 +/- 8.6 (mean +/- S.D.) years, duration of illness at the first MRI study 2.1 +/- 1.1 years, duration of illness at the last study 9.7 +/- 2.6 years, and the follow-up duration 7.6 +/- 2.3 years. Controls were 85 neurologically intact persons (60.2 +/- 11.1 years age). In the MRI study, measurements of the ratio of each area to the intracranial area were performed for the cerebral hemisphere, frontal, temporal and parietal-occipital lobes. A significant progression of atrophy to under the normal limit was observed in the cerebrum, frontal and temporal lobes. Besides the typical pathological lesions in MSA, five autopsied patients revealed frontal lobe atrophy with mild gliosis, mild demyelination and glial cytoplasmic inclusions (GCIs). One of these patients showed remarkable frontal lobe atrophy with degenerative changes in the cerebral cortex. We observed the involvement of the cerebral hemisphere, especially the frontal lobe. (C) 2002 Elsevier Science B.V. All rights reserved.