Segregation and linkage analysis for longitudinal measurements of a quantitative trait
Segregation and linkage analysis for longitudinal measurements of a quantitative trait
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DOI：
10.1186/1471-2156-4-s1-s21
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发表时间：
2003-12-31
期刊：
影响因子：
2.9
通讯作者：
Gauderman, WJ
中科院分区：
文献类型：
--
作者：
Gee, C;Morrison, JL;Gauderman, WJ
我们提出了一种方法，使用斜率和截距从一个数量性状的线性回归的分离和连锁分析的结果。我们应用该方法来分析纵向收缩压（SBP）数据从心脏研究。将第一阶段线性模型拟合到每例受试者的SBP测量值，以估计其随时间的斜率和截距，后者按比例表示平均观察年龄（53.7岁）时的平均SBP。然后使用分离和连锁分析分析受试者特异性截距和斜率。我们描述了一种使用第一阶段截距和斜率的标准误差作为遗传分析中的权重的方法。对于截取物，我们发现了孟德尔基因在分离分析中的显著证据，并且对于染色体1、3、5、9、10和17上的特定标记物，提示连锁结果（LOD分数大于或等于1.5）。然而，对于斜率，数据不支持孟德尔模型，因此未进行正式的连锁分析。
We present a method for using slopes and intercepts from a linear regression of a quantitative trait as outcomes in segregation and linkage analyses. We apply the method to the analysis of longitudinal systolic blood pressure ( SBP) data from the Framingham Heart Study. A first-stage linear model was fit to each subject's SBP measurements to estimate both their slope over time and an intercept, the latter scaled to represent the mean SBP at the average observed age (53.7 years). The subject-specific intercepts and slopes were then analyzed using segregation and linkage analysis. We describe a method for using the standard errors of the first-stage intercepts and slopes as weights in the genetic analyses. For the intercepts, we found significant evidence of a Mendelian gene in segregation analysis and suggestive linkage results ( with LOD scores greater than or equal to 1.5) for specific markers on chromosomes 1, 3, 5, 9, 10, and 17. For the slopes, however, the data did not support a Mendelian model, and thus no formal linkage analyses were conducted.