Toward synthetic biology with engineered T cells: a long journey just begun.
Toward synthetic biology with engineered T cells: a long journey just begun.
复制标题
利用工程化 T 细胞迈向合成生物学：漫长的旅程才刚刚开始。
DOI：
10.1089/hum.2014.2533
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发表时间：
2014
影响因子：
4.2
通讯作者：
June,CarlH
中科院分区：
文献类型：
--
作者：
June,CarlH
这是一个荣誉提供回顾性评论，因为我们进入了一个显着的时代，基因转移治疗，最终将提供治愈一些目前无法治愈的疾病。就像在几乎所有领域一样，目前的进展是通过扩大前人的进展而取得的。弗里德曼为那些刚接触这门学科的人记录了这一领域的起源（Friedmann and Roblin，1972; Friedmann，1992）。从我自己的经验来看，我怀疑所有在基因转移成功的门槛上发挥作用的研究人员都有三个共同点。首先，每一位研究者都必须具备非凡的智慧，才能在反复的实验失败面前坚持下去;此外，当这个领域被其他生物医学研究领域普遍轻视时，这个领域的研究者必须坚持下去。第二，基因转移技术领域的所有高级研究人员都有一个共同的特点，那就是他们的注意力持续时间非常长，在大多数情况下，他们的注意力持续了几十年。最后，我怀疑所有的基因治疗先驱都有多学科的兴趣，并且对多任务处理感到满意，这是在这个多学科领域转化基础科学进步所必需的品质。以下是我的团队所面临的一些经验和我们所遇到的挑战中的教训。
It is an honor to provide retrospective comments as we enter a remarkable era of gene transfer therapy that will ultimately provide cures for a number of presently incurable diseases. As in nearly all fields, the present advances have been made by extending the advances of our predecessors. Friedmann has chronicled the origins of the field for those new to this discipline (Friedmann and Roblin, 1972; Friedmann, 1992). From my own experiences, I suspect that there are three qualities in common with all of the investigators who have had a role in bringing gene transfer to the threshold of success. First, each investigator must possess a remarkable degree of stubbornness to persist in the face of repeated experimental failures; further, investigators in this field had to persist when the field was held in generally low regard by other fields of biomedical research. Second, all of the senior investigators in gene transfer technologies share the attribute of having an extraordinarily long attention span, which in most cases spans several decades of sustained effort. Finally, I suspect that all gene therapy pioneers have multidisciplinary interests, and are comfortable with multitasking, a quality that is necessary to translate basic science advances in this multidisciplinary field. Below are some of the experiences that my team has faced and lessons from the challenges that we have encountered.