Emerging role of lncRNAs in renal fibrosis
Emerging role of lncRNAs in renal fibrosis
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lncRNA 在肾纤维化中的新作用
DOI：
10.1016/j.abb.2020.108530
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发表时间：
2020-10-15
影响因子：
3.9
通讯作者：
Zhou, Jun
中科院分区：
文献类型：
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作者：
Chen, Hongtao;Fan, Youling;Zhou, Jun
纤维化是各种慢性肾脏病（CKD）的最终共同病理特征。然而，对肾纤维化发展的机制的理解仍然具有挑战性和争议性。非编码RNA（noncoding RNAs，ncRNA）是目前分子生物学研究的热点，主要包括microRNA（miRNAs）、长链非编码RNA（longnoncoding RNAs，lncRNA）和环状非编码RNA（circular noncoding RNAs，circRNA），它们具有强大而丰富的生物学功能，是各种系统疾病生理和病理过程的重要介质。ncRNA在肾纤维化中的作用近年来也受到了极大的关注，但大多数研究主要集中在miRNA上。事实上，尽管最近出现了大量关于lncRNA的研究，但这些分子在肾纤维化中所起的作用至今尚未完全了解。本文就lncRNA的发现及其在不同类型肾纤维化中的生物学功能，以及这些发现在临床上的应用作一综述。毫无疑问，在未来，进一步了解所有类型的lncRNA的功能将揭示肾纤维化治疗的重大突破。
Fibrosis is the final common pathological feature of a wide variety of chronic kidney disease (CKD). However, an understanding of the mechanisms underlying the development of renal fibrosis remains challenging and controversial. As the current focus of molecular research, noncoding RNAs (ncRNAs), mainly microRNAs (miRNAs), long noncoding RNAs (lncRNAs) and circular noncoding RNAs (circRNAs), have powerful and abundant biological functions, which essentially makes them mediators of the physiological and pathological processes of various system diseases. The role of ncRNAs in renal fibrosis has also received great attention in recent years, but most research has mainly focused on miRNAs. In fact, although a large number of studies of lncRNAs have emerged recently, the role these molecules play in renal fibrosis haven't been fully understood till now. Thus, this review discusses the discovery of lncRNAs and their biological functions in different types of renal fibrosis, as well as the imminent applications of these findings in clinical use. Undoubtedly, in the future, further understanding of the function of all types of lncRNAs will reveal large breakthroughs in the treatment of renal fibrosis.