Knowledge, attitudes and practices of West Africans on genetic studies of stroke: Evidence from the SIREN Study
Knowledge, attitudes and practices of West Africans on genetic studies of stroke: Evidence from the SIREN Study
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DOI：
10.1177/1747493018790059
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发表时间：
2019-01-01
影响因子：
6.7
通讯作者：
Ovbiagele, Bruce
中科院分区：
文献类型：
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作者：
Akinyemi, Rufus O.;Sarfo, Fred S.;Ovbiagele, Bruce
背景评估非洲人中与中风相关的基因组知识是至关重要的，这有助于为已经在非洲开始的基因革命的伦理、法律和社会影响做准备。目的了解西非人对脑卒中遗传学研究的认识、态度和实践情况。方法在加纳和尼日利亚的15个地点招募脑卒中患者和无脑卒中对照者进行比较横断面研究。采用问卷调查的方式评估参与者对中风遗传性的认识、接受基因检测的意愿以及对中风基因研究潜在益处的认知。进行了描述性、频率分布和多元回归分析。结果2029名中风患者中只有49%的人知道中风是一种遗传性疾病，2603名无中风患者中只有57%的人知道中风是一种遗传性疾病。在那些知道的人中，90%的人愿意接受基因检测。对中风遗传性的了解与至少受过高等教育（OR 1.51, 1.25-1.81）和中风家族史（OR 1.20, 1.03-1.39）相关，而伊斯兰教（OR=0.82, CI: 0.72-0.94）、目前未婚（OR= 0.81, CI: 0.70-0.92）和饮酒（OR= 0.78, CI: 0.67-0.91）与中风作为一种遗传性疾病的意识较低相关。接受卒中基因检测的意愿与卒中家族史相关（OR = 1.34, 1.03-1.74），但与高血压病史呈负相关（OR = 0.79, 0.65-0.96）。结论为进一步提高对脑卒中遗传的认识和接受脑卒中基因检测的意愿，教育程度较低、有高血压史和无脑卒中家族史的个体需要有针对性的干预。
Background It is crucial to assess genomic literacy related to stroke among Africans in preparation for the ethical, legal and societal implications of the genetic revolution which has begun in Africa. Objective To assess the knowledge, attitudes and practices (KAP) of West Africans about stroke genetic studies. Methods A comparative cross-sectional study was conducted among stroke patients and stroke-free controls recruited across 15 sites in Ghana and Nigeria. Participants' knowledge of heritability of stroke, willingness to undergo genetic testing and perception of the potential benefits of stroke genetic research were assessed using interviewer-administered questionnaire. Descriptive, frequency distribution and multiple regression analyses were performed. Results Only 49% of 2029 stroke patients and 57% of 2603 stroke-free individuals knew that stroke was a heritable disorder. Among those who knew, 90% were willing to undergo genetic testing. Knowledge of stroke heritability was associated with having at least post-secondary education (OR 1.51, 1.25-1.81) and a family history of stroke (OR 1.20, 1.03-1.39) while Islamic religion (OR=0.82, CI: 0.72-0.94), being currently unmarried (OR = 0.81, CI: 0.70-0.92), and alcohol use (OR = 0.78, CI: 0.67-0.91) were associated with lower odds of awareness of stroke as a heritable disorder. Willingness to undergo genetic testing for stroke was associated with having a family history of stroke (OR 1.34, 1.03-1.74) but inversely associated with a medical history of high blood pressure (OR = 0.79, 0.65-0.96). Conclusion To further improve knowledge of stroke heritability and willingness to embrace genetic testing for stroke, individuals with less formal education, history of high blood pressure and no family history of stroke require targeted interventions.