MORTALITY AND CAUSES OF DEATH IN TYPE-2 DIABETIC-PATIENTS - A LONG-TERM FOLLOW-UP-STUDY IN OSAKA DISTRICT, JAPAN
MORTALITY AND CAUSES OF DEATH IN TYPE-2 DIABETIC-PATIENTS - A LONG-TERM FOLLOW-UP-STUDY IN OSAKA DISTRICT, JAPAN
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DOI：
10.1016/0168-8227(89)90042-9
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发表时间：
1989-01-01
影响因子：
5.1
通讯作者：
UEHARA, M
中科院分区：
文献类型：
--
作者：
SASAKI, A;HORIUCHI, N;UEHARA, M
在日本大坂对1939例糖尿病患者进行了一项随访研究，平均观察期为9.4年。每1000人-年的死亡率男性为31.35人，女性为21.99人，观察到的死亡人数与预期死亡人数之比男性为1.69人，女性为1.74人，表明日本男女糖尿病患者的死亡率均过高，男性死亡率高于女性。与患者预后相关的因素有年龄、空腹血糖水平升高、肥胖指数降低、高血压、糖尿病视网膜病变和蛋白尿。胰岛素治疗也与不良预后相关。糖尿病患者的主要死因为心脑血管疾病和肾脏疾病，其中心脏病占19.5%，脑血管病占16.7%，肾脏疾病占13.1%。值得注意的是，肾脏疾病作为2型糖尿病死亡原因的频率相对较高，特别是在发病年龄较低的患者中，这表明日本和西方国家之间糖尿病的临床表现存在一定差异。恶性肿瘤占死亡人数的25%，肝硬化占6.4%。
A follow-up study of 1939 diabetic patients with a mean observation period of 9.4 years was carried out in Osaka, Japan. The mortality rates per 1000 person-years were 31.35 for males and 21.99 for females, and the ratios of observed to expected number of deaths were 1.69 for males and 1.74 for females, indicating an excess mortality for diabetic patients of both sexes and higher mortality in males than in females in Japan. Factors related to the prognosis of the patients were age, elevated fasting glucose level, lower obesity index, hypertension, diabetic retinopathy, and albuminuria at entry to the study. Insulin treatment was also associated with poor prognosis. Cerebro-cardiovascular and renal disease were the major causes of death in diabetic patients; heart disease killed 19.5%, cerebrovascular disease 16.7% and renal disease 13.1%. The relatively high frequency of renal disease as a cause of death in type 2 diabetes, especially in patients with a lower age of onset, was noteworthy, suggesting some difference in the clinical manifestations of diabetes between Japan and Western countries. Malignant neoplasms accounted for 25% of deaths, and cirrhosis of the liver for 6.4%.