Altered Macular Microvasculature in Mild Cognitive Impairment and Alzheimer Disease.
Altered Macular Microvasculature in Mild Cognitive Impairment and Alzheimer Disease.
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DOI：
10.1097/wno.0000000000000580
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发表时间：
2018-09
期刊：
影响因子：
--
通讯作者：
Wang J
中科院分区：
文献类型：
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作者：
Jiang H;Wei Y;Shi Y;Wright CB;Sun X;Gregori G;Zheng F;Vanner EA;Lam BL;Rundek T;Wang J
分析轻度认知功能障碍（MCI）和阿尔茨海默病（AD）黄斑微血管网的特点。12名AD患者和19名MCI患者与21名年龄范围相似的认知正常（CN）对照一起招募。采用光学相干断层扫描血管造影（OCTA）对黄斑区视网膜微血管网（RVN）、浅血管丛（SVP）和深血管丛（DVP）进行成像。在不同的环形区和象限中进行代表微血管密度的分形分析（盒计数，Dbox）。用Zeiss OCT测量黄斑神经节细胞-内丛状层（GC-IPL）厚度，分析视网膜微血管与临床表现的关系。AD患者的RVN、SVP和DVP在直径为0.6 ~ 2.5mm的纤维环中的密度低于对照组（P < 0.05）。MCI组上级鼻象限DVP密度低于对照组（P < 0.05）。各组间GC-IPL厚度差异无统计学意义（P > 0.05）。血管密度从对照组到MCI组再到AD组呈下降趋势（P < 0.05）。AD患者DVP的视网膜微血管密度与GC-IPL厚度相关（P < 0.05），而MCI患者和对照组的DVP微血管密度与GC-IPL厚度无相关性。AD患者视网膜微血管网密度低于对照组。我们的研究结果表明，存在视网膜微血管功能障碍的AD。
To analyze the macular microvascular network in mild cognitive impairment (MCI) and Alzheimer disease (AD). Twelve AD patients and 19 MCI patients were recruited together with 21 cognitively normal (CN) controls with a similar range of ages. Optical coherence tomography angiography (OCTA) was used to image the retinal microvascular network at the macular region including retinal vascular network (RVN), superficial vascular plexus (SVP), and deep vascular plexus (DVP). Fractal analysis (box counting, Dbox) representing the microvascular density was performed in different annular zones and quadrantal sectors. The macular ganglion cell-inner plexiform layer (GC-IPL) thickness was measured using Zeiss OCT. The relationship between the retinal microvasculature and clinical manifestations was analyzed. AD patients had lower densities of RVN, SVP and DVP in the annulus, from 0.6 to 2.5 mm in diameter (P < 0.05) in comparison to controls. MCI patients had lower density of DVP in the superior nasal quadrant (P < 0.05) than that of the controls. There were no significant differences of GC-IPL thickness among groups (P > 0.05). There was a trend of vascular density loss from control to MCI then AD (P < 0.05). Retinal microvascular density of DVP was correlated to GC-IPL thickness (P < 0.05) in AD patients, but not in MCI patients and controls. AD patients had less density of retinal microvascular networks than controls. Our findings suggest the presence of retinal microvascular dysfunction in AD.