A double-edged function of DDX3, as an oncogene or tumor suppressor, in cancer progression
A double-edged function of DDX3, as an oncogene or tumor suppressor, in cancer progression
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DOI：
10.3892/or.2018.6203
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发表时间：
2018-03-01
期刊：
影响因子：
4.2
通讯作者：
Liang, Shufang
中科院分区：
文献类型：
--
作者：
He, Yu;Zhang, Dan;Liang, Shufang
DEAD-box RNA helicase 3（DDX 3）是一个高度保守的DEAD-box蛋白家族成员，广泛存在于从酵母到人类的所有真核生物中。越来越多的研究已经证实DDX 3具有调节RNA代谢的不同步骤的能力，包括RNA剪接、RNA输出、转录和翻译起始。此外，DDX 3还参与许多生物学过程，如应激反应、细胞凋亡、细胞周期调控和病毒感染。近年来，DDX 3由于其在癌症进展中的重要作用而受到越来越多的关注。然而，DDX 3在癌症发展中的作用相当复杂。本文主要综述DDX 3及其介导的信号通路在多种肿瘤中的双重作用。此外，讨论了DDX 3在癌症中有争议的作用的相互作用的原因。从抗癌活性到DDX 3抑制剂的临床试验，总结了目前几种靶向DDX 3的小分子化合物。
DEAD-box RNA helicase 3 (DDX3) is a highly conserved family member of DEAD-box proteins in all eukaryotes from yeasts to human beings. Accumulating studies have confirmed DDX3 has the ability to regulate different steps of RNA metabolism, including RNA splicing, RNA export, transcription and translation initiation. Moreover, DDX3 is involved in many biological processes, such as stress response, cell apoptosis, cell cycle regulation and virus infection. In recent years, DDX3 is getting increasing attention due to its essential roles in cancer progression. However, DDX3 role in cancer development is rather complicated. This review mainly focuses on the dual roles of DDX3 and DDX3-mediated signaling pathways in multiple cancers. In addition, the interplaying causes for the controversial roles of DDX3 in cancer are discussed. So far several small molecular chemical compounds targeting DDX3 are also summarized from the anticancer activity to the clinical trials of DDX3 inhibitors.