THE GLOBUS-PALLIDUS RECEIVES A PROJECTION FROM THE PARAFASCICULAR NUCLEUS IN THE RAT
THE GLOBUS-PALLIDUS RECEIVES A PROJECTION FROM THE PARAFASCICULAR NUCLEUS IN THE RAT
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DOI：
10.1016/0006-8993(91)90224-j
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发表时间：
1991-07-05
期刊：
影响因子：
2.9
通讯作者：
NEWMAN, SW
中科院分区：
文献类型：
--
作者：
KINCAID, AE;PENNEY, JB;NEWMAN, SW
用荧光金逆行示踪法研究大鼠苍白球（GP）的传入，发现在同侧丘脑束旁核（PF）内有逆行标记的神经元。我们使用了顺行示踪剂。菜豆-白细胞凝集素（PHA-L），以证实和扩展我们的研究结果。在PF中注射PHA-L后，在同侧GP中观察到具有静脉曲张和末端特化的标记纤维。投影的拓扑组织是这样的，外侧和腹侧PF神经元优先投影到GP的相应部分，内侧PF神经元主要投影到腹侧GP。在GP的背侧或内侧有很少的标记纤维。目前描述的从PF到GP的投射为PF影响基底神经节回路提供了额外的途径。
Study of the afferents of the rat globus pallidus (GP) with Fluoro-gold, a retrograde tracer, revealed retrogradely labeled neurons in the ipsilateral parafascicular nucleus of the thalamus (PF), a previously undescribed afferent of the rat GP. We used the anterograde tracer. Phaseolus vulgaris-leucoagglutinin (PHA-L), to confirm and extend our findings. After injections of PHA-L in the PF, labeled fibers with varicosities and terminal specializations were observed in the ipsilateral GP. The topographical organization of the projection is such that lateral and ventral PF neurons project preferentially to respective parts of the GP, and medial PF neurons project primarily to the ventral GP. There were very few labeled fibers seen in the dorsal or medial GP. The presently described projection from the PF to the GP provides an additional route for the PF to influence basal ganglia circuitry.