Presentation of youth with type 2 diabetes in the Pediatric Diabetes Consortium
Presentation of youth with type 2 diabetes in the Pediatric Diabetes Consortium
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DOI：
10.1111/pedi.12281
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发表时间：
2016-06-01
影响因子：
3.4
通讯作者：
Tamborlane, William V.
中科院分区：
文献类型：
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作者：
Klingensmith, Georgeanna J.;Connor, Crystal G.;Tamborlane, William V.
目的：青少年2型糖尿病（T2D）被认为是一种儿科疾病，但很少有报道描述其诊断特征。我们描述了503例青年T2D的临床表现。方法：儿童糖尿病联盟（PDC） T2D临床注册登记了来自美国8个儿童糖尿病中心的T2D参与者。分析诊断时的临床和实验室特征。结果：共有67%的患者表现出糖尿病症状并证实了实验室数据，但33%是通过检测发现的高危儿童，11%表现为糖尿病酮症酸中毒（DKA）， 2%表现为高血糖高渗状态（HHS）。平均年龄为13.1±2.3岁（范围4.6-19.8岁），其中38例（8%）诊断时年龄小于10岁。大多数是女性（65%），西班牙裔（54%），有T2D家族史（92%）。中位体重指数（BMI） z-score为2.3（四分位数范围为2.0-2.6）。不到一半（46%）的人与父母都住在一起，只有30%的人的父母受过高中以上的教育，43%的人的家庭收入为
Objective: Type 2 diabetes (T2D) in youth is recognized as a pediatric disease, but few reports describe the characteristics during diagnosis. We describe the clinical presentation of 503 youth with T2D.Methods: The Pediatric Diabetes Consortium (PDC) T2D Clinic Registry enrolled T2D participants from eight pediatric diabetes centers in the USA. Clinical and laboratory characteristics at the time of diagnosis were analyzed.Results: In total 67% presented with symptoms of diabetes and confirming laboratory data, but 33% were identified by testing at risk children, 11% presented with diabetic ketoacidosis (DKA), and 2% with hyperglycemic hyperosmolar state (HHS). The mean age was 13.1 +/- 2.3 yr (range, 4.6-19.8 yr) with 38 (8%) less than 10 yr of age at diagnosis. The majority was female (65%), Hispanic (54%) and had a family history of T2D (92%). The median body mass index (BMI) z-score was 2.3 (interquartile range 2.0-2.6). Fewer than half (46%) lived with both parents, only 30% had parents with education beyond high school, and 43% lived in a household with an income of