The dorsal premotor cortex encodes the step-by-step planning processes for goal-directed motor behavior in humans
The dorsal premotor cortex encodes the step-by-step planning processes for goal-directed motor behavior in humans
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背侧前运动皮层编码人类目标导向运动行为的逐步规划过程
DOI：
10.1016/j.neuroimage.2022.119221
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发表时间：
2022
期刊：
影响因子：
5.7
通讯作者：
Yukio Nishimura
中科院分区：
文献类型：
--
作者：
Yoshihisa Nakayama;Sho K. Sugawara;Masaki Fukunaga;Yuki H. Hamano;Norihiro Sadato;Yukio Nishimura
背侧前运动皮层（PMd）在视觉引导的目标导向运动行为中起着重要的作用。尽管有几个规划过程可以实现目标导向的行为，但单独的神经过程在很大程度上是未知的。在这里，我们创建了一个新的视觉目标任务，以研究人类视觉和视觉目标行为的逐步规划过程。使用功能性磁共振成像，我们发现激活在不同的部分双边PMd在每个处理步骤。特别是，基于规则的视觉和视觉目标映射的激活区位于双侧PMd的腹侧部分，用于行动计划指定的激活区位于左侧PMd的背尾侧部分，用于转换的激活区位于左侧PMd的吻侧部分，用于行动准备的激活区位于双侧PMd的尾侧部分。因此，左PMd参与了所有的过程，但右PMd只参与基于规则的视觉和视觉目标映射和行动准备。与每个过程相关的位置通常在空间上彼此分离，但它们部分重叠。这些结果表明，在人类的双侧PMd中存在功能亚区，这些亚区形成一个功能梯度，以实现目标导向行为。
The dorsal premotor cortex (PMd) plays an essential role in visually guided goal-directed motor behavior. Although there are several planning processes for achieving goal-directed behavior, the separate neural processes are largely unknown. Here, we created a new visuo-goal task to investigate the step-by-step planning processes for visuomotor and visuo-goal behavior in humans. Using functional magnetic resonance imaging, we found activation in different portions of the bilateral PMd during each processing step. In particular, the activated area for rule-based visuomotor and visuo-goal mapping was located at the ventrorostral portion of the bilateral PMd, that for action plan specification was at the dorsocaudal portion of the left PMd, that for transformation was at the rostral portion of the left PMd, and that for action preparation was at the caudal portion of the bilateral PMd. Thus, the left PMd was involved throughout all of the processes, but the right PMd was involved only in rule-based visuomotor and visuo-goal mapping and action preparation. The locations related to each process were generally spatially separated from each other, but they overlapped partially. These findings revealed that there are functional subregions in the bilateral PMd in humans and these subregions form a functional gradient to achieve goal-directed behavior.