Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes
Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes
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DOI：
10.1261/rna.7240905
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发表时间：
2005-03-01
期刊：
影响因子：
4.5
通讯作者：
Bartel, DP
中科院分区：
文献类型：
--
作者：
Baskerville, S;Bartel, DP
微小RNA（microRNAs，miRNAs）是一种内源性短RNA，在动物和植物中具有转录后抑制基因表达的作用。微阵列分析调查揭示了175种人类miRNA在24种不同人体器官中的表达模式。我们的研究结果表明，近端的miRNA对通常是共表达的。此外，在50 kb的距离处，表达的miRNAs对之间的相关性发生了突然的转变，这意味着被
MicroRNAs (miRNAs) are short endogenous RNAs known to post-transcriptionally repress gene expression in animals and plants. A microarray profiling survey revealed the expression patterns of 175 human miRNAs across 24 different human organs. Our results show that proximal pairs of miRNAs are generally coexpressed. In addition, an abrupt transition in the correlation between pairs of expressed miRNAs occurs at a distance of 50 kb, implying that miRNAs separated by