Genetic characterization of adult infratentorial gliomas
Genetic characterization of adult infratentorial gliomas
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DOI：
10.1007/s11060-008-9714-2
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发表时间：
2009-02-01
影响因子：
3.9
通讯作者：
Kawase, Takeshi
中科院分区：
文献类型：
--
作者：
Miwa, Tomoru;Hirose, Yuichi;Kawase, Takeshi
成人幕下神经胶质瘤很罕见，尚未得到充分研究。因此，我们对这些肿瘤进行了遗传分析，看看是否存在与临床管理和理解肿瘤发生相关的任何特征。通过比较基因组杂交分析 19 例成人幕下神经胶质瘤的染色体畸变，并通过免疫组织化学分析 p53 和表皮生长因子受体 (EGFR) 的表达。最常见的染色体畸变是 7p 的增加，七个小脑或第四脑室恶性神经胶质瘤中有五个有这种畸变。然而，7q 的增加（幕上星形细胞瘤的特征性异常，通常与 7p 的增加相关）仅在 11 例成人幕下星形细胞瘤中的 1 例中观察到。没有观察到少突胶质细胞瘤遗传标志 1p 和 19q 的联合丢失。 p53 和 EGFR 的免疫组织化学结果与幕上神经胶质瘤中报道的结果相当。我们的研究结果可能表明成人幕下神经胶质瘤存在独特的致瘤途径。
Adult infratentorial gliomas are rare and have not been well studied. We therefore conducted genetic analysis of those tumors to see if there was any characteristic that could be relevant in clinical management and understanding of tumorigenesis. Nineteen adult infratentorial gliomas were analyzed for chromosomal aberration by comparative genomic hybridization, and for expression of p53 and epidermal growth factor receptor (EGFR) by immunohistochemistry. The most frequent chromosomal aberration was the gain of 7p, and five of the seven cerebellar or fourth ventricle malignant gliomas had that aberration. However, the gain of 7q, the characteristic abnormality of supratentorial astrocytomas commonly associated with the gaining of 7p, was observed only in 1 of 11 adult infratentorial astrocytic tumors. Combined losses of 1p and 19q, the genetic hallmark of oligodendroglioma, were not observed. Results of immunohistochemistry of p53 and EGFR were comparable to those reported in supratentorial gliomas. Our findings might suggest the presence of distinct tumorigenic pathway in adult infratentorial gliomas.