SYMPATHETIC ACTIVITY FOLLOWING PARAVENTRICULAR OR VENTROMEDIAL HYPOTHALAMIC-LESIONS IN RATS
SYMPATHETIC ACTIVITY FOLLOWING PARAVENTRICULAR OR VENTROMEDIAL HYPOTHALAMIC-LESIONS IN RATS
复制标题
DOI：
10.1016/0361-9230(88)90135-9
复制
发表时间：
1988-04-01
影响因子：
3.8
通讯作者：
EDDLESTONE, G
中科院分区：
文献类型：
--
作者：
SAKAGUCHI, T;BRAY, GA;EDDLESTONE, G
本实验旨在测量下丘脑腹内侧或室旁核急性和慢性损伤大鼠肩胛间棕色脂肪组织的神经丝交感放电率。雌性大鼠分别在室旁核和下丘脑腹内侧注射kainic酸。交感神经活动是通过记录神经丝到肩胛间棕色脂肪组织的放电速率来测量的，这些神经丝安装在连接放大器和速率计的银丝电极上。在损伤后30分钟进行的急性实验中，两组的基础放电率均降低，vmh损伤大鼠的基础放电率明显低于PVN损伤大鼠。在慢性实验中，在VMH或PVN内注射kainic酸，7 ~ 9天后测量交感神经放电率。两个损伤组的增重均高于对照组，但vmh损伤组的增重高于pvn损伤组。vmh损伤大鼠交感神经丝的基础放电率低于其他各组。pvn损伤大鼠与对照组交感神经活动无显著差异。这些实验支持以下假设：下丘脑腹内侧的损伤会减少交感神经活动，而室旁核的损伤则不会。
The present experiment was designed to measure the symapthetic firing rate of nerve filaments to interscapular brown adipose tissue in rats with acute and chronic lesions in the ventromedial hypothalamus or paraventricular nucleus. Female rats received injections of kainic acid into either the paraventricular nucleus or the ventromedial hypothalamus. The sympathetic activity was measured by recording the firing rate of nerve filaments to interscapular brown adipose tissue after mounting the filaments on silver wire electrodes connected to an amplifier and rate meter. In acute experiments performed 30 minutes after the lesion, the basal firing rate was reduced in both groups and was significantly lower in the VMH-lesioned rats than in those with PVN lesions. In the chronic experiment kainic acid was injected into the VMH or PVN and the sympathetic firing rate was measured 7 to 9 days later. Both lesioned groups gained more weight than controls, but the VMH-lesioned rats gained more weight than the PVN-lesioned rats. The basal firing rate of sympathetic nerve filaments in the VMH-lesioned rats was lower than in the other groups. There was no significant difference in the sympathetic activity between PVN-lesioned and control rats. These experiments support the hypothesis that lesions of the ventromedial hypothalamus reduce the sympathetic activity but that lesions in the paraventricular nucleus do not.