Small-molecule inhibitors of DNA damage-repair pathways: an approach to overcome tumor resistance to alkylating anticancer drugs.
Small-molecule inhibitors of DNA damage-repair pathways: an approach to overcome tumor resistance to alkylating anticancer drugs.
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DOI：
10.4155/fmc.12.58
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发表时间：
2012-06
影响因子：
4.2
通讯作者：
Gold B
中科院分区：
文献类型：
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作者：
Srinivasan A;Gold B
癌症治疗未来发展的一个主要挑战是识别生物靶点和途径，以及随后设计分子来对抗几乎所有癌症中隐藏的耐药细胞。这种治疗方法的合理性是基于过去 30 年癌症治疗方面的有限进展，尽管开发了许多新型化疗方法和早期检测，但这些方法常常因耐药性而失败。克服肿瘤耐药性的各种目标之一是 DNA 修复系统，它可以逆转许多临床使用的 DNA 损伤剂的细胞毒性。已经取得了一些进展，但仍有许多工作要做。我们探索了 DNA 修复过程中涉及 DNA 烷基化损伤修复的一些组成部分，作为开发新型有效分子的目标，旨在提高现有抗癌药物的功效。
A major challenge in the future development of cancer therapeutics is the identification of biological targets and pathways, and the subsequent design of molecules to combat the drug-resistant cells hiding in virtually all cancers. This therapeutic approach is justified based upon the limited advances in cancer cures over the past 30 years, despite the development of many novel chemotherapies and earlier detection, which often fail due to drug resistance. Among the various targets to overcome tumor resistance are the DNA repair systems that can reverse the cytotoxicity of many clinically used DNA-damaging agents. Some progress has already been made but much remains to be done. We explore some components of the DNA-repair process, which are involved in repair of alkylation damage of DNA, as targets for the development of novel and effective molecules designed to improve the efficacy of existing anticancer drugs.
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影响因子：
37.3
作者：
Beier D;Schulz JB;Beier CP
通讯作者：
Beier CP
影响因子：
5.1
作者：
Deng, JZ;Starck, SR;Hemling, ME
通讯作者：
Hemling, ME
影响因子：
11.5
作者：
Bobola, MS;Finn, LS;Silber, JR
通讯作者：
Silber, JR
影响因子：
2.2
作者：
Boeckmann, Lars;Nickel, Ann-Christin;Emmert, Steffen
通讯作者：
Emmert, Steffen
DOI：
10.1038/nrc3088
发表时间：
2011-06-24
期刊：
Nature reviews. Cancer
影响因子：
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作者：
通讯作者：
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