CLINICAL PHARMACOLOGY OF ANTINEOPLASTIC AGENTS .1.
CLINICAL PHARMACOLOGY OF ANTINEOPLASTIC AGENTS .1.
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DOI：
10.1056/nejm197505222922107
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发表时间：
1975-01-01
影响因子：
158.5
通讯作者：
JOHNS, DG
中科院分区：
文献类型：
--
作者：
CHABNER, BA;MYERS, CE;JOHNS, DG
肿瘤学作为一个医学分支的出现与有效的化疗的发展密切相关。对肿瘤细胞生物化学和各种抗肿瘤药物的作用的基础研究为这一努力做出了显着贡献，近年来，临床药理学在处理宿主毒性、肿瘤敏感性和耐药性以及治疗方案方面变得越来越重要。本文的目的是回顾这类药物药理学的最新进展，强调可能影响药物治疗临床效果的因素。
THE emergence of oncology as a medical subspecialty has been closely allied to the development of effective antineoplastic chemotherapy. Basic research into tumor-cell biochemistry and the effects of various antitumor agents have contributed markedly to this effort, and in recent years clinical pharmacology has become increasingly important in dealing with problems of host toxicity, tumor sensitivity and resistance, and therapeutic scheduling. It is the purpose of this article to review recent advances in the pharmacology of this class of drugs, emphasizing the factors that are likely to influence the clinical effectiveness of antineoplastic therapy.MethotrexateSince . . .