Estimation of viscoelasticity of radial artery via simultaneous measurement of changes in pressure and diameter using a single ultrasound probe
Estimation of viscoelasticity of radial artery via simultaneous measurement of changes in pressure and diameter using a single ultrasound probe
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DOI：
10.35848/1347-4065/ab7f1c
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发表时间：
2020-07-01
影响因子：
1.5
通讯作者：
Kanai, Hiroshi
中科院分区：
文献类型：
--
作者：
Saito, Takumi;Mori, Shohei;Kanai, Hiroshi
为了建立血管内皮功能的评价指标，我们开发了一种超声探头，可以测量桡动脉同一位置的血压和血管直径的变化。基于体模实验，使用超声波探头元件的压电效应测量的压力波形和使用压力传感器测量的压力波形表现出高相关性（相关系数：r = 0.979 - 0.999）。我们从体内实验中确认了血压变化与直径之间关系的连续测量。然后，我们可以通过预先将探头元件的输出校准为绝对血压值来估计粘弹性的变化。弹性和粘度的平均变异系数分别为0.02和0.24。这项研究表明，由于使用开发的超声探头流量介导的扩张测量的桡动脉壁的粘弹性模量的变化的可能性。(C)2020日本应用物理学会
To establish an evaluation index for vascular endothelial function, we developed an ultrasonic probe that can measure changes in blood pressure and blood vessel diameter at the same position in the radial artery. Based on phantom experiments, the pressure waveforms measured using the piezoelectric effect of the ultrasonic probe element and those using a pressure sensor exhibited a high correlation (correlation coefficient: r = 0.979 - 0.999). We confirmed the continuous measurement of the relationship between changes in blood pressure and the diameter from the in vivo experiments. We could then estimate the changes in viscoelasticity by calibrating the output from the probe element to the absolute blood pressure values in advance. The average coefficients of variations were 0.02 and 0.24 for elasticity and viscosity, respectively. This study demonstrated the possibility of measuring changes in the viscoelastic moduli of the radial arterial wall due to flow-mediated dilation using the developed ultrasonic probe. (C) 2020 The Japan Society of Applied Physics