Endoplasmic Reticulum-Mitochondria Contacts: A Potential Therapy Target for Cardiovascular Remodeling-Associated Diseases.
Endoplasmic Reticulum-Mitochondria Contacts: A Potential Therapy Target for Cardiovascular Remodeling-Associated Diseases.
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DOI：
10.3389/fcell.2021.774989
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发表时间：
2021
影响因子：
5.5
通讯作者：
Li C
中科院分区：
文献类型：
--
作者：
Wang Y;Zhang X;Wen Y;Li S;Lu X;Xu R;Li C
在慢性缺血性心脏病、慢性超负荷心脏病、心肌炎、心肌梗死等多种心脏疾病引起的心功能不全的进展过程中，心肌细胞、胶原网、血管床均发生心血管重构。由于重塑而发生的形态学变化是重大疾病发生和发展的重要病理基础，也决定着发病率和死亡率。因此，抑制重塑是预防和治疗心力衰竭等相关疾病的重要途径。内质网（ER）和线粒体通过内质网-线粒体接触（ermc）紧密连接。ermc主要通过参与脂质代谢、钙稳态、线粒体功能、内质网应激、自噬等多种细胞生命过程，在不同的信号通路中发挥重要作用，为内质网和线粒体相互作用、维持细胞正常功能提供了满意的结构平台。研究表明，ermc异常可促进重构的发生和发展，参与多种心血管重构相关疾病的形成。本文就ermc的结构、功能以及ermc参与心血管重塑的潜在机制进行综述，提示ermc可能成为心血管重塑性疾病治疗新策略的潜在靶点。
Cardiovascular remodeling occurs in cardiomyocytes, collagen meshes, and vascular beds in the progress of cardiac insufficiency caused by a variety of cardiac diseases such as chronic ischemic heart disease, chronic overload heart disease, myocarditis, and myocardial infarction. The morphological changes that occur as a result of remodeling are the critical pathological basis for the occurrence and development of serious diseases and also determine morbidity and mortality. Therefore, the inhibition of remodeling is an important approach to prevent and treat heart failure and other related diseases. The endoplasmic reticulum (ER) and mitochondria are tightly linked by ER-mitochondria contacts (ERMCs). ERMCs play a vital role in different signaling pathways and provide a satisfactory structural platform for the ER and mitochondria to interact and maintain the normal function of cells, mainly by involving various cellular life processes such as lipid metabolism, calcium homeostasis, mitochondrial function, ER stress, and autophagy. Studies have shown that abnormal ERMCs may promote the occurrence and development of remodeling and participate in the formation of a variety of cardiovascular remodeling-associated diseases. This review focuses on the structure and function of the ERMCs, and the potential mechanism of ERMCs involved in cardiovascular remodeling, indicating that ERMCs may be a potential target for new therapeutic strategies against cardiovascular remodeling-induced diseases.
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DOI：
10.1083/jcb.126.6.1375
发表时间：
1994-09
期刊：
The Journal of cell biology
影响因子：
--
作者：
Burgess SM;Delannoy M;Jensen RE
通讯作者：
Jensen RE
影响因子：
5.3
作者：
Bozi LH;Jannig PR;Rolim N;Voltarelli VA;Dourado PM;Wisløff U;Brum PC
通讯作者：
Brum PC
影响因子：
64.5
作者：
Cárdenas C;Miller RA;Smith I;Bui T;Molgó J;Müller M;Vais H;Cheung KH;Yang J;Parker I;Thompson CB;Birnbaum MJ;Hallows KR;Foskett JK
通讯作者：
Foskett JK
影响因子：
16
作者：
Bhola PD;Letai A
通讯作者：
Letai A
影响因子：
9.3
作者：
Basso, Valentina;Marchesan, Elena;Ziviani, Elena
通讯作者：
Ziviani, Elena