Toward Computer-Aided Biology
Toward Computer-Aided Biology
复制标题
走向计算机辅助生物学
DOI：
10.11234/gi1990.7.280
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
H. Kitano
中科院分区：
文献类型：
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作者：
H. Kitano
近年来，计算机技术在生物学领域得到越来越多的关注，特别是在人类基因组计划领域，在该领域正在获得压倒性的数据。目前，计算机被广泛应用于序列比对、蛋白质结构预测、代谢途径数据库等方面。本文讨论了我们对计算机技术在生物学中可能的新用途的研究工作。目前，正在开展两个项目，虚拟细胞实验室项目和完美线虫项目。虚拟细胞实验室是利用计算机模拟抽象分子动力学、转录调控和细胞间相互作用的尝试。它密切复制体外细胞培养实验。我们应用该系统研究了细胞衰老的可能机制，并获得了一些有意义的结果。完美线虫项目的目标是对线虫进行详细的建模，以便进行各种虚拟实验，同时也是一个C。优雅生物学家
Recently, computer technologies has been getting increasing attention in biology, particularly in the area of the human genome project, where overwhelming data is being acquired. Currently, computers are used intensively for the sequence alignment, protein structure prediction, metabolic pathway data-base, etc. In this paper, we discuss our research efforts on the possible new use of computer technology for biology. Currently, two projects are being carried out Virtual Cell Laboratory project and Perfect C elegans project. Virtual Cell Laboratory is an attempt to use computer simulation for abstract molecular dynamics, transcription regulations, and cell-cell interactions. It closely replicate in vitro cell culture experiments. We applied this system to investigate a possible mechanism of cellular senescence, and gained insightful results. Perfect C elegans project aims at detailed modeling of the menatode C elegans, so that various virtual experiments can be carried out, as well as being a tool for C. elegans biologists.