High-strength resorbable brushite bone cement with controlled drug-releasing capabilities
High-strength resorbable brushite bone cement with controlled drug-releasing capabilities
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DOI：
10.1016/j.actbio.2008.08.005
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发表时间：
2009-01-01
影响因子：
9.7
通讯作者：
Barralet, J. E.
中科院分区：
文献类型：
--
作者：
Hofmann, M. P.;Mohammed, A. R.;Barralet, J. E.
水镁石水泥与形成磷灰石的组合物的不同之处在于在它们的凝固反应中消耗大量的水，而形成磷灰石的水泥消耗很少或根本不消耗水。只有在凝固过程中消耗水的这种水泥体系理论上才能生产出接近零孔隙率的陶瓷。本研究旨在生产这种透钙磷石陶瓷，并研究孔隙率的几乎消除是否会防止现有磷酸钙骨水泥递送基质常见的掺入抗生素的突释曲线。通过调节粉末反应物的粉末工艺性能，即颗粒尺寸和颗粒尺寸分布，并通过将液相的柠檬酸浓度调节至800 mM，可以实现透钙磷石水泥基质的低至11%的相对孔隙率（与以前的研究相比减少了60%），导致52 MPa的湿未预压抗压强度（表示比先前报道的结果增加超过100%），水泥浆的可工作凝固时间为4.5分钟。至多2重量%的万古霉素和环丙沙星可以掺入到水泥系统中而不损失湿抗压强度。结果发现，药物释放速率可以通过骨水泥系统的可调节的相对孔隙率来控制，并且可以最小化突释并且实现几乎线性的释放，但是抗生素（万古霉素>环丙沙星）的溶解度似乎也是一个关键因素。(C)2008 Acta Materialia Inc.由爱思唯尔有限公司出版。保留所有权利。
Brushite cements differ from apatite-forming compositions by consuming a lot of water in their setting reaction whereas apatite-forming cements consume little or no water at all. Only such cement systems that consume water during setting can theoretically produce near-zero porosity ceramics. This study aimed to produce such a brushite ceramic and investigated whether near elimination of porosity would prevent a burst release profile of incorporated antibiotics that is common to prior calcium phosphate cement delivery matrices. Through adjustment of the powder technological properties of the powder reactants, that is particle size and particle size distribution, and by adjusting citric acid concentration of the liquid phase to 800 mM, a relative porosity of as low as 11% of the brushite cement matrix could be achieved (a 60% reduction compared to previous studies), resulting in a wet unprecompacted compressive strength of 52 MPa (representing a more than 100% increase to previously reported results) with a workable setting time of 4.5 min of the cement paste. Up to 2 wt.% of vancomycin and ciprofloxacin could be incorporated into the cement system without loss of wet compressive strength. It was found that drug release rates could be controlled by the adjustable relative porosity of the cement system and burst release could be minimized and an almost linear release achieved, but the solubility of the antibiotic (vancomycin > ciprofloxacin) appeared also to be a crucial factor. (C) 2008 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.